Neural function of Bmal1: an overview

Cell & Bioscience

Review

Meng Zhang¹  Feixue Wang¹  Yucen Xia¹  Jinglan Yan¹  Taiyi Wang¹  Lin Yao¹  Yuanjia Zheng²  Yongjun Chen³  Jie Lin⁴  Lingyun Pan⁴  Zhenwei Ding⁴  Hongjie Chen⁴  Kelin Deng⁴  Yuqi Zheng⁴  Kaitong Zhang⁴  Xiaoye Xia⁴  Zhikai Su⁵ 

[1] Research Institute of Acupuncture and Moxibustion, Shandong University of Traditional Chinese Medicine, Jinan, China;Research Institute of Acupuncture and Moxibustion, Shandong University of Traditional Chinese Medicine, Jinan, China;South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, China;Research Institute of Acupuncture and Moxibustion, Shandong University of Traditional Chinese Medicine, Jinan, China;South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, China;Center for Brain Science and Brain-Inspired Intelligence, Guangdong-Hong Kong-Macao Greater Bay Area, Guangzhou, China;South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, China;The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China;

关键词: Bmal1;    Pleiotropy;    Neurobiology;    Neural function;    Mental disorder;    Biological clock;   

DOI  :  10.1186/s13578-022-00947-8

 received in 2022-11-10, accepted in 2022-12-19,  发布年份 2022

来源: Springer

【 摘 要 】

Bmal1 (Brain and muscle arnt-like, or Arntl) is a bHLH/PAS domain transcription factor central to the transcription/translation feedback loop of the biologic clock. Although Bmal1 is well-established as a major regulator of circadian rhythm, a growing number of studies in recent years have shown that dysfunction of Bmal1 underlies a variety of psychiatric, neurodegenerative-like, and endocrine metabolism-related disorders, as well as potential oncogenic roles. In this review, we systematically summarized Bmal1 expression in different brain regions, its neurological functions related or not to circadian rhythm and biological clock, and pathological phenotypes arising from Bmal1 knockout. This review also discusses oscillation and rhythmicity, especially in the suprachiasmatic nucleus, and provides perspective on future progress in Bmal1 research.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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Fig. 2