Novel lipid indicators and the risk of type 2 diabetes mellitus among Chinese hypertensive patients: findings from the Guangzhou Heart Study

Cardiovascular Diabetology

Research

Maohua Yuan¹  Hai Deng²  Murui Zheng³  Xueru Duan⁴  Miaochan Lao⁵  Huanning Zhou⁶  Xiang Qian Lao⁷  Xiuyi Wu⁸  Wenjing Zhao⁹  Xudong Liu^1,10  Chuchu Wu^1,10  Peng Hu^1,11  Huoxing Li^1,12 

[1] Dadong Street Community Health Service Center, 510080, Guangzhou, China;Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Science, 510080, Guangzhou, China;Department of Community Health, Guangzhou Center for Disease Control and Prevention, No. 1 Qide Road, Baiyun District, 510440, Guangzhou, China;Department of Epidemiology, School of Public Health, Sun Yat-Sen University, 510080, Guangzhou, China;Department of Sleep Center, Department of Geriatric Respiratory, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangdong Provincial Geriatrics Institute, 510080, Guangzhou, China;Guangzhou Yuexiu District Center for Disease Control and Prevention, Guangzhou, China;JC School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, 999077, Hong Kong, SAR, China;Nancun Community Health Service Center, 511442, Guangzhou, China;School of Public Health and Emergency Management, Southern University of Science and Technology, No. 1088 Xueyuan Avenue, 518055, Shenzhen, China;School of Public Health, Guangdong Pharmaceutical University, No. 283 Jianghai Avenue, Haizhu District, 510310, Guangzhou, China;School of Public Health, Guangdong Pharmaceutical University, No. 283 Jianghai Avenue, Haizhu District, 510310, Guangzhou, China;Department of Epidemiology, School of Public Health, Sun Yat-Sen University, 510080, Guangzhou, China;The Second School of Clinical Medicine, Southern Medical University, 510515, Guangzhou, China;

关键词: Hypertriglyceridemic-waist phenotype;    Triglyceride glucose index;    Lipid accumulation product;    Visceral adiposity index;    Diabetes;    Hypertension;   

DOI  :  10.1186/s12933-022-01660-z

 received in 2022-09-08, accepted in 2022-10-03,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundData are limited on whether several easily measured indices are independent predictors of type 2 diabetes mellitus (T2DM) in hypertensive patients. This study aimed to assess the association of hypertriglyceridemic-waist phenotype, triglyceride glucose (TyG) index, lipid accumulation product (LAP), and visceral adiposity index (VAI) with T2DM risk in hypertensive patients.MethodsThis cross-sectional study included 5321 hypertensive patients from the baseline survey of the Guangzhou Heart Study. Face-to-face questionnaire survey, physical examination, and fasting blood sample collection were completed for all subjects. Odds ratio (OR) with 95% confidence interval (95% CI) were calculated by using the logistic regression model. The potential nonlinear relationship was examined using restricted cubic spline regression.ResultsThe prevalence of T2DM was 19.98% among hypertensive patients. After adjusting for confounders, participants with elevated triglyceride levels and enlarged waist circumference (HTGW) were associated with a 2.57-fold risk of T2DM (OR 2.57, 95% CI 2.05, 3.23). When comparing with subjects within the lowest quartile of the indices, those in the highest quartile of TyG, LAP, and VAI were associated with 5.35-fold (95% CI 4.33, 6.64), 2.65-fold (95% CI 2.11, 3.34), and 2.17-fold (95% CI 1.77, 2.67) risk of T2DM after adjusting for confounders. Every 1-unit increment of TyG, LAP, and VAI was associated with 81%, 38%, and 31% increased risk of T2DM, respectively. The nonlinear association was observed for TyG, LAP, and VAI (all PNon-linear < 0.001).ConclusionsThe results found that among hypertensive patients, HTGW and a higher level of TyG, LAP, and VAI were associated with an elevated risk of T2DM. The findings suggested that HTGW, TyG, LAP, and VAI may serve as simple and effective tools for T2DM risk assessment in the prevention and management of main chronic diseases.

【 授权许可】

CC BY   
© The Author(s) 2022. corrected publication 2022

【 图 表 】

Fig. 1

41116_2022_35_Article_IEq433.gif

12888_2022_4443_Article_IEq10.gif

41116_2022_35_Article_IEq425.gif

41116_2022_35_Article_IEq421.gif