Berberin sustained-release nanoparticles were enriched in infarcted rat myocardium and resolved inflammation

Journal of Nanobiotechnology

Research

Fuqiang Shao¹  Kun Wang²  Yangmeihui Song³  Zhangyongxue Zhou³  Ziyang Zhu³  Ke Zhu⁴  Chunxia Qin⁵  Dawei Jiang⁵  Xiaoli Lan⁵  Yu Yao⁶ 

[1] Department of Nuclear Medicine, The First People’s Hospital of Zigong, Zigong, Sichuan, China;Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Ave, 430022, Wuhan, Hubei, China;Department of Nuclear Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China;Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Ave, 430022, Wuhan, Hubei, China;Hubei Key Laboratory of Molecular Imaging, 430022, Wuhan, Hubei, China;Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Ave, 430022, Wuhan, Hubei, China;Hubei Key Laboratory of Molecular Imaging, 430022, Wuhan, Hubei, China;Department of Nuclear Medicine, The First People’s Hospital of Zigong, Zigong, Sichuan, China;Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Ave, 430022, Wuhan, Hubei, China;Hubei Key Laboratory of Molecular Imaging, 430022, Wuhan, Hubei, China;Key Laboratory of Biological Targeted Therapy, The Ministry of Education, 430022, Wuhan, Hubei, China;Department of Ultrasound, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China;

关键词: Myocardial infarction;    Inflammation;    Berberin;    Nanoparticle;    Targeted;    Sustained release;   

DOI  :  10.1186/s12951-023-01790-w

 received in 2022-12-15, accepted in 2023-01-20,  发布年份 2023

来源: Springer

【 摘 要 】

Inflammatory regulation induced by macrophage polarization is essential for cardiac repair after myocardial infarction (MI). Berberin (BBR) is an isoquinoline tetrasystemic alkaloid extracted from plants. This study analyzes the most likely mechanism of BBR in MI treatment determined via network pharmacology, showing that BBR acts mainly through inflammatory responses. Because platelets (PLTs) can be enriched in the infarcted myocardium, PLT membrane-coated polylactic-co-glycolic acid (PLGA) nanoparticles (BBR@PLGA@PLT NPs) are used, which show enrichment in the infarcted myocardium to deliver BBR sustainably. Compared with PLGA nanoparticles, BBR@PLGA@PLT NPs are more enriched in the infarcted myocardium and exhibit less uptake in the liver. On day three after MI, BBR@PLGA@PLT NPs administration significantly increases the number of repaired macrophages and decreases the number of inflammatory macrophages and apoptotic cells in infarcted rat myocardium. On the 28th day after MI, the BBR@PLGA@PLT group exhibits a protective effect on cardiac function, reduced cardiac collagen deposition, improved scar tissue stiffness, and an excellent angiogenesis effect. In addition, BBR@PLGA@PLT group has no significant impact on major organs either histologically or enzymologically. In summary, the therapeutic effect of BBR@PLGA@PLT NPs on MI is presented in detail from the perspective of the resolution of inflammation, and a new solution for MI treatment is proposed.Graphical Abstract

【 授权许可】

CC BY   
© The Author(s) 2023

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