Psoralea corylifolia L.: a comprehensive review of its botany, traditional uses, phytochemistry, pharmacology, toxicology, quality control and pharmacokinetics

Chinese Medicine

Review

Lele Chen¹  Peng Sun¹  Xinyue Liu¹  Jiafeng Wang¹  Shuguang Chen¹  Zhaoshuang Zhan¹ 

[1] College of Chinese Medicine, Shandong University of Traditional Chinese Medicine, No.4655 Daxue Road, 250355, Jinan, China;

关键词: Psoralea corylifolia;    Traditional uses;    Phytochemistry;    Pharmacology;    Toxicology;    Quality control;   

DOI  :  10.1186/s13020-022-00704-6

 received in 2022-11-12, accepted in 2022-12-25,  发布年份 2022

来源: Springer

【 摘 要 】

Psoralea corylifolia L. (PCL), referred to as “Bu-gu-zhi” in Chinese, has great medicinal values since ancient times. PCL is the dried ripe fruit of Psoralea corylifolia L., which has been widely used in traditional Chinese medicine (TCM) for the treatment of kidney-yang deficiency, enuresis and urinary frequency, chills and pain of the waist and knees, dawn diarrhea and vitiligo. In this paper, a systematic of the botany, traditional uses, phytochemistry, pharmacology, toxicology, quality control and pharmacokinetics of PCL was presented, along with future research directions. According to the results, PCL contains approximately 163 chemical components, including coumarins, flavonoids, monoterpene phenols, benzofurans, glycosides, lipids, fatty acids, and volatile oils. PCL and its active ingredients have a variety of pharmacological activities, such as anti-inflammatory, antibacterial, antiviral, antioxidant, antitumor, antiosteoporosis, cardioprotective, neuroprotective, and immunomodulatory. Further study of quality control standards and potential mechanisms of PCL is also needed. In addition, more toxicological studies will also contribute to the progress of clinical trials.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

Fig. 6

Fig. 6

41116_2022_35_Article_IEq96.gif

41116_2022_35_Article_IEq94.gif

41116_2022_35_Article_IEq92.gif

Fig. 1

Fig. 1