A combination of Beers and STOPP criteria better detects potentially inappropriate medications use among older hospitalized patients with chronic diseases and polypharmacy: a multicenter cross-sectional study

BMC Geriatrics

Research

Kun Yang¹  Xianghua Fang¹  Yang Lin²  Shicai Chen³  Hongyan Gu⁴  Pengmei Li⁵  Dechun Jiang⁶  Suying Yan⁶  Su Su⁶  Jing Tang⁶  Ke Wang⁶ 

[1] Department of Evidence-Based Medicine, Xuanwu Hospital, the First Clinical Medical College of Capital Medical University, 100053, Beijing, China;Department of Pharmacy, Beijing Anzhen Hospital Affiliated to Capital Medical University, 100029, Beijing, China;Department of Pharmacy, Beijing Luhe Hospital Affiliated to Capital Medical University, 101149, Beijing, China;Department of Pharmacy, Beijing Shijitan Hospital Affiliated to Capital Medical University, 100038, Beijing, China;Department of Pharmacy, China-Japan Friendship Hospital, 100029, Beijing, China;Department of Pharmacy, Xuanwu Hospital, the First Clinical Medical College of Capital Medical University, No. 45, Changchun Street, 100053, Beijing, Xicheng District, China;National Clinical Research Center for Geriatric Disorders, 100053, Beijing, China;

关键词: Polypharmacy;    Inappropriate prescribing;    Potentially inappropriate medication;    Medication related problems;    Aged;    Chronic disease;   

DOI  :  10.1186/s12877-023-03743-2

 received in 2022-06-20, accepted in 2023-01-10,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundResearch on potentially inappropriate medications (PIM) and medication-related problems (MRP) among the Chinese population with chronic diseases and polypharmacy is insufficient.ObjectivesThis study aimed to investigate the prevalence of PIM and MRP among older Chinese hospitalized patients with chronic diseases and polypharmacy and analyze the associated factors.MethodsA retrospective cross-sectional study was conducted in five tertiary hospitals in Beijing. Patients aged ≥ 65 years with at least one chronic disease and taking at least five or more medications were included. Data were extracted from the hospitals’ electronic medical record systems. PIM was evaluated according to the 2015 Beers criteria and the 2014 Screening Tool of Older Persons’ Prescriptions (STOPP) criteria. MRPs were assessed and classified according to the Helper-Strand classification system. The prevalence of PIM and MRP and related factors were analyzed.ResultsA total of 852 cases were included. The prevalence of PIM was 85.3% and 59.7% based on the Beers criteria and the STOPP criteria. A total of 456 MRPs occurred in 247 patients. The most prevalent MRP categories were dosages that were too low and unnecessary medication therapies. Hyperpolypharmacy (taking ≥ 10 drugs) (odds ratio OR 3.736, 95% confidence interval CI 1.541–9.058, P = 0.004) and suffering from coronary heart disease (OR 2.620, 95%CI 1.090–6.297, P = 0.031) were the influencing factors of inappropriate prescribing (the presence of either PIM or MRP in a patient).ConclusionPIM and MRP were prevalent in older patients with chronic disease and polypharmacy in Chinese hospitals. More interventions are urgently needed to reduce PIM use and improve the quality of drug therapies.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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