Lipid accumulation product, visceral adiposity index and risk of chronic kidney disease

BMC Nephrology

Research

Suzanne E. Judd¹  Mary Cushman²  Pranav S. Garimella³  Ujjala Kumar³  Holly J. Kramer⁴  Mark J. Sarnak⁵  Orlando M. Gutierrez⁶  Ronit Katz⁷  Michael G. Shlipak⁸  Alexander L. Bullen⁹  Joachim H. Ix⁹ 

[1] Department of Biostatistics, UAB School of Public Health, Birmingham, AL, USA;Division of Hematology and Oncology, University of Vermont, Colchester, VT, USA;Division of Nephrology & Hypertension, University of California San Diego, 200 W Arbor Dr.. M/C 8409 MPF L030, 92103, San Diego, CA, USA;Division of Nephrology and Hypertension, Loyola University Medical Center, Maywood, IL, USA;Division of Nephrology, Tufts Medical Center, Boston, MA, USA;Division of Nephrology, UAB Heersink School of Medicine, Birmingham, AL, USA;Division of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA;Kidney Health Research Collaborative, Department of Medicine, University of California, San Francisco, CA, USA;Department of Medicine, San Francisco VA Medical Center, San Francisco, CA, USA;Nephrology Section, Veterans Affairs San Diego Healthcare System, La Jolla, CA, USA;Division of Nephrology & Hypertension, University of California San Diego, 200 W Arbor Dr.. M/C 8409 MPF L030, 92103, San Diego, CA, USA;

关键词: Obesity markers;    Chronic kidney disease;    Albuminuria;    Kidney failure;   

DOI  :  10.1186/s12882-022-03026-9

 received in 2022-07-28, accepted in 2022-11-30,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundLipid accumulation product (LAP) and visceral adiposity index (VAI) are novel, non-imaging markers of visceral adiposity that are calculated by using body mass index (BMI), waist circumference (WC) and serum lipid concentrations. We hypothesized that LAP and VAI are more strongly associated with adverse kidney outcomes than BMI and WC.MethodsUsing data from the REasons for Geographic and Racial Differences in Stroke (REGARDS) study, we used multivariable logistic regression to evaluate associations of LAP, VAI, BMI and WC with incident chronic kidney disease (CKD), (incident eGFR < 60 ml/min/1.73m2 and > 25% decline).ResultsAmong the overall cohort of 27,550 participants, the mean baseline age was 65 years; 54% were women; and 41% were African American. After a median of 9.4 years (IQR 8.6, 9.9) of follow-up, a total of 1127 cases of incident CKD were observed. Each two-fold higher value of VAI (OR 1.12, 95% CI 1.04, 1.20), LAP (OR 1.21, 95% CI 1.13, 1.29), WC (OR 2.10, 95% CI 1.60, 2.76) and BMI (OR: 2.66, 95% CI 1.88, 3.77), was associated with greater odds of incident CKD.ConclusionsLAP and VAI as measures of visceral adiposity are associated with higher odds of incident CKD but may not provide information beyond WC and BMI.

【 授权许可】

CC BY   
© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2022

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