Characteristics of oral microbiome of healthcare workers in different clinical scenarios: a cross-sectional analysis

BMC Oral Health

Research

Zhiming Shi¹  Lili Zhao²  Xinqian Ma²  Jianbo Xue²  Wenyi Yu²  Yukun He²  Zhancheng Gao³  Yue Wei⁴  Shuming Guo⁵  Jing Wu⁵  Zhixia Zhang⁵  Yu Zhu⁶  Guangyao Li⁶  Siqin Liu⁷ 

[1] Cardiology Department, Linfen Central Hospital, Hainan, Shanxi, China;Department of Respiratory and Critical Care Medicine, Peking University People’s Hospital, Beijing, China;Department of Respiratory and Critical Care Medicine, Peking University People’s Hospital, Beijing, China;Department of Pulmonary and Critical Care Medicine, Peking University People’s Hospital, 100044, Beijing, China;Nursing College of Shanxi Medical University, Shanxi, China;Nursing Department, Linfen Central Hospital, 041000, Shanxi, Shanxi, China;Science and Education Department, Linfen Central Hospital, Hainan, Shanxi, China;The Stomatology College of Binzhou Medical University, Yantai, Shandong, China;

关键词: Healthcare institutes;    Coronary care unit;    Healthcare worker;    16S rRNA;    Oral microbiome;    Microbial alteration;   

DOI  :  10.1186/s12903-022-02501-x

 received in 2022-05-18, accepted in 2022-10-12,  发布年份 2022

来源: Springer

【 摘 要 】

The environment of healthcare institutes (HCIs) potentially affects the internal microecology of medical workers, which is reflected not only in the well-studied gut microbiome but also in the more susceptible oral microbiome. We conducted a prospective cross-sectional cohort study in four hospital departments in Central China. Oropharyngeal swabs from 65 healthcare workers were collected and analyzed using 16S rRNA gene amplicon sequencing. The oral microbiome of healthcare workers exhibited prominent deviations in diversity, microbial structure, and predicted function. The coronary care unit (CCU) samples exhibited robust features and stability, with significantly higher abundances of genera such as Haemophilus, Fusobacterium, and Streptococcus, and a lower abundance of Prevotella. Functional prediction analysis showed that vitamin, nucleotide, and amino acid metabolisms were significantly different among the four departments. The CCU group was at a potential risk of developing periodontal disease owing to the increased abundance of F. nucleatum. Additionally, oral microbial diversification of healthcare workers was related to seniority. We described the oral microbiome profile of healthcare workers in different clinical scenarios and demonstrated that community diversity, structure, and potential functions differed markedly among departments. Intense modulation of the oral microbiome of healthcare workers occurs because of their original departments, especially in the CCU.

【 授权许可】

CC BY   
© The Author(s) 2022

【 图 表 】

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