期刊论文详细信息
European Journal of Medical Research
Quercetin inhibits the progression of endometrial HEC-1-A cells by regulating ferroptosis—a preliminary study
Research
Xiaoqin Li1  Qianqian Zhu2  Meng Ma2  Haiyan Guo2 
[1] Biobank of Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, No. 115, Jinzun Road, 200011, Shanghai, China;Department of Assisted Reproduction, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Research Center for Specialty Strategy of China Hospital Development Institute, Shanghai Jiao Tong University, 200011, Shanghai, China;
关键词: Endometrial carcinoma;    Quercetin;    Ferroptosis;    Mechanism;   
DOI  :  10.1186/s40001-022-00934-2
 received in 2022-10-20, accepted in 2022-12-04,  发布年份 2022
来源: Springer
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【 摘 要 】

BackgroundEndometrial carcinoma (EC) is one of the most common female reproductive system tumors, which seriously threatens women's health. This preliminary study aimed to investigate the effects of quercetin on the EC cells and explore the potential mechanism.MethodsIn this study, the effects of quercetin on endometrial cancer HEC-1-A cells were studied by a series of cell biological methods, including CCK-8 detection of cell activity, Western blotting of ferroptosis-related proteins, apoptosis detection, reactive oxygen species (ROS) detection and other detections.ResultsOur results showed that quercetin inhibited the proliferation and migration of EC cells, induced cell apoptosis, and affected the cell cycle. Furthermore, the anti-tumor effect of quercetin was related to the induction of ferroptosis in the EC cells.ConclusionsOur study shows quercetin may exert anti-tumor effects, which may be related to the regulation of ferroptosis. Our study provides evidence for the future treatment of EC with small molecule drugs.

【 授权许可】

CC BY   
© The Author(s) 2022

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