Emerging roles of mechanosensitive ion channels in acute lung injury/acute respiratory distress syndrome

Respiratory Research

Review

Shanglong Yao¹  Qi Jia¹  Yiyi Yang¹  Xiangdong Chen¹  Zhiqiang Hu¹ 

[1] Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;

关键词: Acute lung injury/acute respiratory distress syndrome;    Mechanosensitive ion channels;    Epithelial sodium channel;    Piezo channels;    Transient receptor potential channels;    Two-pore domain potassium ion channels;   

DOI  :  10.1186/s12931-022-02303-3

 received in 2022-03-17, accepted in 2022-12-16,  发布年份 2022

来源: Springer

【 摘 要 】

Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a devastating respiratory disorder with high rates of mortality and morbidity, but the detailed underlying mechanisms of ALI/ARDS remain largely unknown. Mechanosensitive ion channels (MSCs), including epithelial sodium channel (ENaC), Piezo channels, transient receptor potential channels (TRPs), and two-pore domain potassium ion (K2P) channels, are highly expressed in lung tissues, and the activity of these MSCs can be modulated by mechanical forces (e.g., mechanical ventilation) and other stimuli (e.g., LPS, hyperoxia). Dysfunction of MSCs has been found in various types of ALI/ARDS, and MSCs play a key role in regulating alveolar fluid clearance, alveolar epithelial/endothelial barrier function, the inflammatory response and surfactant secretion in ALI/ARDS lungs. Targeting MSCs exerts therapeutic effects in the treatment of ALI/ARDS. In this review, we summarize the structure and functions of several well-recognized MSCs, the role of MSCs in the pathogenesis of ALI/ARDS and recent advances in the pharmacological and molecular modulation of MSCs in the treatment of ALI/ARDS. According to the current literature, targeting MSCs might be a very promising therapeutic approach against ALI/ARDS.

【 授权许可】

CC BY   
© The Author(s) 2022

【 图 表 】

Fig. 1