Piezo Channels: Awesome Mechanosensitive Structures in Cellular Mechanotransduction and Their Role in Bone

International Journal of Molecular Sciences

Shujing Liang¹  Airong Qian¹  Lifang Hu¹  Zixiang Wu¹  Xia Xu¹  Zhihao Chen¹  Hua Liu¹  Kang Ru¹  Yunxian Jia¹  Zarnaz Khan¹  Shuyu Liu¹ 

[1] Lab for Bone Metabolism, Key Lab for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an 710072, China;

关键词: Piezo channels;    mechanotransduction;    bone cells;    bone disease;   

DOI  :  10.3390/ijms22126429

来源: DOAJ

【 摘 要 】

Piezo channels are mechanosensitive ion channels located in the cell membrane and function as key cellular mechanotransducers for converting mechanical stimuli into electrochemical signals. Emerged as key molecular detectors of mechanical forces, Piezo channels’ functions in bone have attracted more and more attention. Here, we summarize the current knowledge of Piezo channels and review the research advances of Piezo channels’ function in bone by highlighting Piezo1′s role in bone cells, including osteocyte, bone marrow mesenchymal stem cell (BM-MSC), osteoblast, osteoclast, and chondrocyte. Moreover, the role of Piezo channels in bone diseases is summarized.

【 授权许可】

Unknown