The effects of neutral argon plasma versus electrocoagulation on tissue in advanced-stage ovarian cancer: a case series

Journal of Ovarian Research

Research

Heleen J. van Beekhuizen¹  Xu Shan Gao¹  Nick J. van de Berg²  Gatske M. Nieuwenhuyzen-de Boer³  Patricia C. Ewing-Graham⁴ 

[1] Department of Gynecologic Oncology, Erasmus MC Cancer Institute, P.O. Box 2040, 3000CA, Rotterdam, The Netherlands;Department of Gynecologic Oncology, Erasmus MC Cancer Institute, P.O. Box 2040, 3000CA, Rotterdam, The Netherlands;Department of Biomechanical Engineering, Delft University of Technology, Delft, The Netherlands;Department of Gynecologic Oncology, Erasmus MC Cancer Institute, P.O. Box 2040, 3000CA, Rotterdam, The Netherlands;Department of Obstetrics and Gynecology, Albert Schweitzer Hospital, Dordrecht, The Netherlands;Department of Pathology, Erasmus University MC, University Medical Center, Rotterdam, The Netherlands;

关键词: Ovarian cancer;    Ovarian neoplasms;    Cytoreductive surgery;    Histology;    Thermal damage depth;    Neutral argon plasma;    PlasmaJet®;    Electrocoagulation;   

DOI  :  10.1186/s13048-022-01070-5

 received in 2021-11-22, accepted in 2022-12-07,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundThe aim of surgery for advanced-stage ovarian cancer is a complete cytoreduction, because this is the most important independent prognostic factor for prolonged survival. Yet this can be difficult to achieve when there are micrometastases on the intestinal mesentery or intestines. The PlasmaJet device is an instrument to remove these micrometastases, but little is known about the depth of damage in human tissue compared to electrocoagulation devices.MethodsA prospective study was performed for the ex-vivo comparison of the histological depth of thermal damage of neutral argon plasma (PlasmaJet®) and electrocoagulation devices, in a series of 106 histological slides of 17 advanced-stage ovarian cancer patients. Depending on the tissue types resected during complete cytoreductive surgery, samples were collected from reproductive organs (uterus, ovaries), intestines (ileum, colon, rectum) and omentum, intestinal mesentery and peritoneum.ResultsAverage thermal damage depth was 0.15 mm (range 0.03–0.60 mm) after use of neutral argon plasma and 0.33 mm (range 0.08–1.80 mm) after use of electrocoagulation (p < 0.001). Greater disruption of the tissue surface was often observed after electrocoagulation.ConclusionOur case series suggests that the use of neutral argon plasma during cytoreductive surgery produces significantly less thermal damage than electrocoagulation treatment. It is therefore considered a thermally safe alternative, aiding in the achievement of cytoreductive surgery.

【 授权许可】

CC BY   
© The Author(s) 2022

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