The correlation between IgM and IgG antibodies with blood profile in patients infected with severe acute respiratory syndrome coronavirus

Clinical and Molecular Allergy

Research

Hassan Ehteram¹  Saeed Sayyah²  Amirreza Ostadian²  Hossein Nikzad²  Elahe Seyed Hosseini²  Narjes Riahi Kashani²  Zahra Alibolandi²  Hamed Haddad Kashani²  Mahdi Sepehrnejad²  Mohammad Hajijafari³  Mohammd-Javad Azadchehr⁴  Hamid Reza Banafshe⁵ 

[1] Anatomical Sciences Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran;Department of Pathology, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran;Anatomical Sciences Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran;Gametogenesis Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran;Department of Anesthesiology, Beheshti Hospital, Kashan University of Medical Sciences, Kashan, Iran;Department of Biostatistics, Infectious Disease Research Center, Kashan University of Medical Sciences, Kashan, Iran;Department of Pharmacology, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran;

关键词: COVID-19;    SARS-CoV-2;    Illness severity;    IgG;    IgM;   

DOI  :  10.1186/s12948-022-00180-1

 received in 2022-03-27, accepted in 2022-10-07,  发布年份 2022

来源: Springer

【 摘 要 】

ObjectivesThis study aimed to determine the levels of IgM and IgG antibody response to the severe acute respiratory syndrome coronavirus (SARS-CoV)-2 in coronavirus disease 2019 (COVID-19) patients with different disease severity.MethodsIgM and IgG antibody levels were evaluated via enzyme-linked immunosorbent assay (ELISA). In total, 100 patients with confirmed SARS-CoV-2 infection were enrolled in this study and viral RNA was detected by using Real-time PCR technique. Clinical and laboratory data were collected and analyzed after hospital admission for COVID-19 and two months post-admission.ResultsThe level of anti-SARS-CoV-2 antibody IgG was significantly higher in the severe patients than those in moderate and mild groups, 2 months after admission. Also, level of IgG was positively associated with increased WBC, NUT and LYM counts in sever than mild or moderate groups after admission to hospital.ConclusionOur findings suggested that patients with severe illness might experience longer virus exposure times and have a stronger antibody response against viral infection. Thus, they have longer time immunity compared with other groups.

【 授权许可】

CC BY   
© The Author(s) 2022

【 图 表 】

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Fig. 1