Dynamics of anti-SARS-CoV-2 IgG antibodies post-COVID-19 in a Brazilian Amazon population

BMC Infectious Diseases

Isabella Pinheiro Costa do Amaral¹  Gergiane Lopes Vaz¹  Izaura Maria Vieira Cayres Vallinoto²  Ednelza da Silva Graça Amoras²  Carlos David Araújo Bichara³  Maria Karoliny da Silva Torres⁴  Maria Alice Freitas Queiroz⁴  Antonio Carlos Rosário Vallinoto⁴  Cléa Nazaré Carneiro Bichara⁵ 

[1] Amaral Costa Diagnostic Medicine, Belém, Pará, Brazil;Laboratory of Virology, Institute of Biological Sciences, Federal University of Pará (UFPA), Belém, Pará, Brazil;Laboratory of Virology, Institute of Biological Sciences, Federal University of Pará (UFPA), Belém, Pará, Brazil;Amaral Costa Diagnostic Medicine, Belém, Pará, Brazil;Graduate Program in Biology of Infectious and Parasitic Agents, Institute of Biological Sciences, Federal University of Pará (UFPA), Belém, Pará, Brazil;Laboratory of Virology, Institute of Biological Sciences, Federal University of Pará (UFPA), Belém, Pará, Brazil;Graduate Program in Biology of Infectious and Parasitic Agents, Institute of Biological Sciences, Federal University of Pará (UFPA), Belém, Pará, Brazil;School of Medicine, Center for Biological and Health Sciences, Pará State University (UEPA), Belém, Pará, Brazil;

关键词: COVID-19;    SARS-CoV-2;    IgG;    Amazon;   

DOI  :  10.1186/s12879-021-06156-x

来源: Springer

【 摘 要 】

BackgroundIn this study, the prevalence and persistence of anti-SARS-CoV-2 (severe acute respiratory syndrome-coronavirus) IgG was evaluated in volunteers 90 days after COVID-19 (coronavirus disease 2019) diagnosis by correlating response dynamics with clinical conditions, epidemiological characteristics, and disease severity.MethodsThe study recruited 200 volunteers aged 18 years or older of both sexes diagnosed with COVID-19. Of the 200 volunteers initially selected, the 135 individuals who underwent serological testing for anti-SARS-CoV-2 antibodies on the first visit to the laboratory, were invited to return, after 90 days, and provide a new blood sample for a second assessment of the presence of anti-SARS-CoV-2 IgG antibody. Disease severity and longevity of symptoms were evaluated for each individual and associated with the serological profile.ResultsAmong the 135 individuals who underwent a previous serological test for anti-SARS-CoV-2 antibody, 125 showed reactivity to IgG (92.6%). Of the 125 individuals with detectable IgG in the first test, 87 (69.6%) showed persistence of this antibody after 90 days and 38 (30.4%) lost IgG reactivity in the second evaluation. The frequency of all reported symptoms was higher in individuals who maintained IgG persistence after 90 days of symptoms. Symptom manifestations lasted ≥21 days in the group with a persistent IgG response (39.6%) and ≤ 7 days in the group with a nonpersistent IgG response (50.0%). The length of hospital stay and supplemental oxygen use were higher in individuals with a persistent IgG response.ConclusionsThe results of the present study show a high frequency of loss of anti-SARS-CoV-2 IgG antibodies within 3 months after COVID-19 diagnosis in the Brazilian Amazon.

【 授权许可】

CC BY