CT texture analysis and node-RADS CT score of mediastinal lymph nodes - diagnostic performance in lung cancer patients

Cancer Imaging

Research Article

Hans-Jonas Meyer¹  Jakob Leonhardi¹  Benedikt Schnarkowski¹  Timm Denecke¹  Anne-Kathrin Höhn²  Hubert Wirtz³  Johanna Pappisch³  Teresa Kerkhoff³  Armin Frille⁴  Sebastian Krämer⁵ 

[1] Department of Diagnostic and Interventional Radiology, University of Leipzig, Leipzig, Germany;Department of Pathology, University Hospital Leipzig, University of Leipzig, Leipzig, Germany;Department of Respiratory Medicine, University Hospital Leipzig, University of Leipzig, Leipzig, Germany;Department of Respiratory Medicine, University Hospital Leipzig, University of Leipzig, Leipzig, Germany;Integrated Research and Treatment Centre (IFB) Adiposity Diseases, University Medical Centre Leipzig, Leipzig, Germany;Department of Thoracic Surgery, University Hospital Leipzig, University of Leipzig, Leipzig, Germany;

关键词: Computed tomography;    Lymph node;    Lung cancer;    Texture;   

DOI  :  10.1186/s40644-022-00506-x

 received in 2022-06-22, accepted in 2022-12-07,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundTexture analysis derived from computed tomography (CT) can provide clinically relevant imaging biomarkers. Node-RADS is a recently proposed classification to categorize lymph nodes in radiological images. The present study sought to investigate the diagnostic abilities of CT texture analysis and Node-RADS to discriminate benign from malignant mediastinal lymph nodes in patients with lung cancer.MethodsNinety-one patients (n = 32 females, 35%) with a mean age of 64.8 ± 10.8 years were included in this retrospective study. Texture analysis was performed using the free available Mazda software. All lymph nodes were scored accordingly to the Node-RADS classification. All primary tumors and all investigated mediastinal lymph nodes were histopathologically confirmed during clinical workup.ResultsIn discrimination analysis, Node-RADS score showed statistically significant differences between N0 and N1-3 (p < 0.001). Multiple texture features were different between benign and malignant lymph nodes: S(1,0)AngScMom, S(1,0)SumEntrp, S(1,0)Entropy, S(0,1)SumAverg. Correlation analysis revealed positive associations between the texture features with Node-RADS score: S(4,0)Entropy (r = 0.72, p < 0.001), S(3,0) Entropy (r = 0.72, p < 0.001), S(2,2)Entropy (r = 0.72, p < 0.001).ConclusionsSeveral texture features and Node-RADS derived from CT were associated with the malignancy of mediastinal lymph nodes and might therefore be helpful for discrimination purposes. Both of the two quantitative assessments could be translated and used in clinical routine.

【 授权许可】

CC BY   
© The Author(s) 2022

【 图 表 】

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