Assessing the efficacy of myopia control in monocular orthokeratology treated unilateral myopic children

BMC Ophthalmology

Research

Xiaoli Kang¹  Lingyan Dong¹  Jun Yu¹  Peiquan Zhao¹  Jie Cen¹  Yiye Chen¹  Ce Zheng¹  Rong Zhu¹ 

[1] Department of Ophthalmology, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 KongJiang Road, 200092, Shanghai, China;

关键词: Orthokeratology;    Myopia control;    Efficacy;    Axial length;   

DOI  :  10.1186/s12886-022-02693-4

 received in 2022-08-04, accepted in 2022-11-18,  发布年份 2022

来源: Springer

【 摘 要 】

PurposeTo investigate the efficacy of myopia control by comparing the orthokeratology (Ortho-K) treated eyes and the emmetropic contralateral eyes in unilateral myopic children, and to identify the inter-individual influence factors.MethodIn this retrospective study, 1566 medical records of children wearing Ortho-K lens were reviewed, and 62 children who received monocular Ortho-K lens for more than 1 year were analyzed. The change in axial length (AL) of the Ortho-K eyes and the emmetropic contralateral eyes was recorded. To evaluate the absolute and relative efficacy of myopia control, the intra-bilateral absolute reduction in AL growth (ibARAL) and the intra-bilateral relative reduction in AL growth (ibRRAL) were calculated as main outcomes. Association of the AL elongation, ibARAL and ibRRAL with age, sex and ocular parameters was analyzed by correlation analysis and generalized estimating equation (GEE) analysis.ResultThe average initial wearing age was 10.76 ± 1.45 (ranged 8.5 to 15.8). The average baseline SER was − 2.15 ± 1.03 (ranged − 5.25 to -1.00) D in the Ortho-K eyes and − 0.01 ± 0.40 (ranged − 0.75 to 0.75) D in the contralateral eyes. At the 1-year follow-up, the average increased AL was significantly less in the Ortho-K eyes (0.07 ± 0.18 mm) than in the fellow eyes (0.48 ± 0.24 mm) (p < 0.001). The mean ibARAL was 0.41 ± 0.30 mm, and the mean ibRRAL was 83.4%±56.3%. In the GEE model, the AL change in Ortho-K eyes (β = 0.051, p = 0.009, 95%CI: 0.012 to 0.090), the ibARAL (β= -0.153, p = 0.000, 95%CI: -0.228 to -0.078) and the ibRRAL (β= -0.196, p = 0.020, 95%CI: -0.361 to -0.030) were independently associated with the spherical equivalent refraction (SER) of the Ortho-K eyes, after adjusting for age, sex, and keratometry.ConclusionIn our study, the Ortho-K treatment was efficacious in controlling axial length growth in the monocular orthokeratology treated unilateral myopic eyes. The efficacy increased when the myopia was more severe. In the children from 8 to 16 years old, the effectiveness was independent of age and sex.

【 授权许可】

CC BY   
© The Author(s) 2022

【 图 表 】

Fig. 1

12982_2022_119_Article_IEq207.gif

12982_2022_119_Article_IEq65.gif