Prevalence of type-1 interferon autoantibodies in adults with non-COVID-19 acute respiratory failure

Respiratory Research

Correspondence

Anthea Mitchell¹  Grace Wang¹  Joseph L. DeRisi²  Mark S. Anderson³  Natasha Spottiswoode⁴  Charles R. Langelier⁵  Carolyn S. Calfee⁶  Rajani Ghale⁷ 

[1] Department of Biochemistry and Biophysics, University of California, San Francisco, CA, USA;Department of Biochemistry and Biophysics, University of California, San Francisco, CA, USA;Chan Zuckerberg Biohub, San Francisco, CA, USA;Department of Medicine, University of California, San Francisco, CA, USA;Diabetes Center, University of California, San Francisco, CA, USA;Division of Infectious Diseases, University of California, San Francisco, CA, USA;Department of Medicine, University of California, San Francisco, CA, USA;Division of Infectious Diseases, University of California, San Francisco, CA, USA;Department of Medicine, University of California, San Francisco, CA, USA;Chan Zuckerberg Biohub, San Francisco, CA, USA;Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, University of California, San Francisco, CA, USA;Department of Medicine, University of California, San Francisco, CA, USA;Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, University of California, San Francisco, CA, USA;Division of Infectious Diseases, University of California, San Francisco, CA, USA;Department of Medicine, University of California, San Francisco, CA, USA;

关键词: COVID-19;    Auto-antibodies;    Type I interferon;    Anti-interferon antibodies;    Acute respiratory failure;   

DOI  :  10.1186/s12931-022-02283-4

 received in 2022-05-13, accepted in 2022-12-07,  发布年份 2022

来源: Springer

【 摘 要 】

Auto-antibodies (Abs) to type I interferons (IFNs) are found in up to 25% of patients with severe COVID-19, and are implicated in disease pathogenesis. It has remained unknown, however, whether type I IFN auto-Abs are unique to COVID-19, or are also found in other types of severe respiratory illnesses. To address this, we studied a prospective cohort of 284 adults with acute respiratory failure due to causes other than COVID-19. We measured type I IFN auto-Abs by radio ligand binding assay and screened for respiratory viruses using clinical PCR and metagenomic sequencing. Three patients (1.1%) tested positive for type I IFN auto-Abs, and each had a different underlying clinical presentation. Of the 35 patients found to have viral infections, only one patient tested positive for type I IFN auto-Abs. Together, our data suggest that type I IFN auto-Abs are uncommon in critically ill patients with acute respiratory failure due to causes other than COVID-19.

【 授权许可】

CC BY   
© The Author(s) 2022

【 图 表 】

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