Enhanced delivery of a low dose of aducanumab via FUS in 5×FAD mice, an AD model

Translational Neurodegeneration

Research

Hye-Sun Kim¹  Jin Woo Chang²  Won Seok Chang²  Junwon Park²  Chanho Kong²  Jaewoo Shin²  Seong-Wook Park³  Chang-Han Lee⁴  Eun-Jeong Yang⁵  Si-Hyun Kim⁵  Hyunju Kim⁵ 

[1] Department of Biomedical Sciences, College of Medicine, Seoul National University, 103 Daehakro, Jongro-Gu, Seoul, Republic of Korea;Bundang Hospital, Seoul National University College of Medicine, Bundang-Gu, Sungnam, Republic of Korea;Department of Neurosurgery, Yonsei University College of Medicine, 50 Yonsei-Ro, Seodaemun-Gu, Seoul, Republic of Korea;Department of Pharmacology, College of Medicine, Seoul National University, 103 Daehakro, Jongro-Gu, Seoul, Republic of Korea;Department of Pharmacology, College of Medicine, Seoul National University, 103 Daehakro, Jongro-Gu, Seoul, Republic of Korea;Department of Biomedical Sciences, College of Medicine, Seoul National University, 103 Daehakro, Jongro-Gu, Seoul, Republic of Korea;Department of Pharmacology, College of Medicine, Seoul National University, 103 Daehakro, Jongro-Gu, Seoul, Republic of Korea;Neuroscience Research Center, College of Medicine, Seoul National University, 103 Daehakro, Jongro-Gu, Seoul, Republic of Korea;

关键词: Aducanumab;    Alzheimer’s disease;    Focused ultrasound;    Transcriptome profiling;   

DOI  :  10.1186/s40035-022-00333-x

 received in 2022-07-26, accepted in 2022-12-08,  发布年份 2022

来源: Springer

【 授权许可】

CC BY   
© The Author(s) 2022

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