ELN missense variant in patient with mid-aortic syndrome case report

BMC Cardiovascular Disorders

Case Report

Thao Nguyen Phan¹  Long Hoang Luong¹  The Huy Nguyen¹  Hoang Duc Nguyen¹  Tran Thuy Nguyen² 

[1] National E Hospital, Hanoi, Vietnam;VNU University of Medicine and Pharmacy, 144 Xuan Thuy Street, Cau Giay, Hanoi, Vietnam;

关键词: Mid-aortic syndrome;    ELN;    ELN;    Klinefelter syndrome;    Loss-of-function mutation;    Abdominal aorta;    Stenosis;    Stroke;    Coarctation;    Elastin;   

DOI  :  10.1186/s12872-022-02965-3

 received in 2022-03-14, accepted in 2022-11-19,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundMid-aortic syndrome (MAS) is characterized by the congenital coarctation of the abdominal aorta, abdominal and limb claudication, and hypertension. The etiology of this disorder is very diverse and often manifests in conjunction with Takayasu's arteritis, Williams-Beurens syndrome, and neurofibromatosis. The isolated mid-aortic syndrome is very rare with only a few cases reported in the literature.Case presentationA 45 years old man was admitted to the Emergency Department with sudden muscle weakness and facial paralysis on the left side. Imaging studies reveal right middle cerebral artery infarction at the M1 section. Incidental findings include multiple moderate to severe stenoses in the right internal carotid artery, and total abdominal aorta occlusion. A variant at the ELN gene (Elastin, OMIM*130,160): c.1768G > A/wt (p.Ala590Thr) was identified.ConclusionThis is the first reported case of ELN related mid-aortic syndrome in Vietnam which was diagnosed through careful clinical and genetic workup. The finding of mid-aortic syndrome, in this case, was incidental and the decision to reverse the occlusion was postponed as there was no immediate risk of renal failure or reduced blood flow to the lower limb.

【 授权许可】

CC BY   
© The Author(s) 2022