Ursolic acid: a natural modulator of signaling networks in different cancers

Cancer Cell International

Review

Amna Hafeez¹  Khushbukhat Khan¹  Anees ur Rahman¹  Muhammad Irfan¹  Sameen Zafar¹  Muhammad Armaghan¹  Iulia-Cristina Bagiu²  Radu Vasile Bagiu³  Javad Sharifi-Rad⁴  Eda Sönmez Gürer⁵  Monica Butnariu⁶ 

[1] Department of Healthcare Biotechnology, Atta-Ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad, Punjab, Pakistan;Department of Microbiology, Victor Babes University of Medicine and Pharmacy of Timisoara, Timisoara, Romania;Multidisciplinary Research Center on Antimicrobial Resistance, Timisoara, Romania;Department of Microbiology, Victor Babes University of Medicine and Pharmacy of Timisoara, Timisoara, Romania;Preventive Medicine Study Center, Timisoara, Romania;Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador;Faculty of Pharmacy, Department of Pharmacognosy, Sivas Cumhuriyet University, Sivas, Turkey;University of Life Sciences “King Mihai I” from Timisoara, Calea Aradului 119, 300645, Timis, Romania;

关键词: Ursolic acid;    Natural compound;    Drug resistance;    Cell signaling;    Anti-cancer potential;   

DOI  :  10.1186/s12935-022-02804-7

 received in 2022-08-31, accepted in 2022-11-24,  发布年份 2022

来源: Springer

【 摘 要 】

Incidence rate of cancer is estimated to increase by 40% in 2030. Furthermore, the development of resistance against currently available treatment strategies has contributed to the cancer-associated mortality. Scientists are now looking for the solutions that could help prevent the disease occurrence and could provide a pain-free treatment alternative for cancers. Therefore, efforts are now put to find a potent natural compound that could sever this purpose. Ursolic acid (UA), a triterpene acid, has potential to inhibit the tumor progression and induce sensitization to conventional treatment drugs has been documented. Though, UA is a hydrophobic compound therefore it is usually chemically modified to increase its bioavailability prior to administration. However, a thorough literature indicating its mechanism of action and limitations for its use at clinical level was not reviewed. Therefore, the current study was designed to highlight the potential mechanism of UA, its anti-cancer properties, and potential applications as therapeutic compound. This endeavour is a valuable contribution in understanding the hurdles preventing the translation of its potential at clinical level and provides foundations to design new studies that could help enhance its bioavailability and anti-cancer potential for various cancers.

【 授权许可】

CC BY   
© The Author(s) 2022

【 图 表 】

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