Presentation of SLE after COVID vaccination in a pediatric patient

BMC Rheumatology

Case Report

Larry A. Greenbaum¹  Heather Rytting²  Meghan Corrigan Nelson³  Baruch Goldberg³ 

[1] Children’s Healthcare of Atlanta, Atlanta, USA;Division of Pediatric Nephrology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA;Division of Pathology, Children’s Healthcare of Atlanta, Atlanta, USA;Division of Pediatric Rheumatology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA;Children’s Healthcare of Atlanta, Atlanta, USA;

关键词: Systemic lupus erythematosus;    COVID-19;    Vaccination;    SARS-CoV2;    Lupus nephritis;    Case report;   

DOI  :  10.1186/s41927-022-00313-8

 received in 2022-06-16, accepted in 2022-10-05,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundThe outbreak of severe acute respiratory syndrome coronavirus 2 has had an enormous impact on global health. Vaccination remains one of the most effective interventions for disease prevention. Clinically significant vaccine side effects are uncommon, though autoimmune-mediated disease occurs in a small percentage of vaccine recipients. Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease that is associated with significant morbidity and mortality. Childhood-onset SLE tends to have more severe disease manifestations than adult-onset SLE. In adults, there are a few reported cases of SLE developing soon after coronavirus disease 2019 (COVID-19) mRNA vaccination.Case presentationA 14-year-old previously healthy male developed laboratory and clinical evidence of SLE, including maculopapular malar rash, arthritis, pleuritic chest pain, and class V (membranous) lupus nephritis, 2 days after his third dose of the Pfizer-BioNTech COVID-19 vaccine. The patient’s symptoms improved after initiation of prednisone and mycophenolate mofetil. We also summarize eleven prior case reports describing SLE after COVID-19 vaccine in adults.ConclusionTo our knowledge, this is the first reported pediatric patient with new onset SLE following COVID-19 mRNA vaccination. While potential mechanistic links exist between COVID-19 vaccination and SLE development, additional studies are necessary to elucidate the exact nature of this relationship.

【 授权许可】

CC BY   
© The Author(s) 2022

【 图 表 】

Fig. 4