Pro-inflammatory diet and depressive symptoms in the healthcare setting

BMC Psychiatry

Research

Courtney Hereford¹  Emily Boothe²  Lance Ridpath³  Rachel Belliveau⁴  Sydney Horton⁵  Robert Foster⁶ 

[1] Center for Rural and Community Health, West Virginia School of Osteopathic Medicine, 400 N Lee St, Lewisburg, WV, USA;Department of Psychiatry, Princeton Community Hospital, 122 12th St, Princeton, WV, USA;Institutional Research Assessment Educational Development, West Virginia School of Osteopathic Medicine, 400 N Lee St, Lewisburg, WV, USA;University of North Carolina Health Care, 2201 S Sterling St, Morganton, NC, USA;University of Texas Health Science Center at Tyler, 11937 US-271, Tyler, TX, USA;West Virginia School of Osteopathic Medicine, 400 N Lee St, Lewisburg, WV, USA;

关键词: Depression;    Nutrition;    Empirical dietary inflammatory index (EDII);    Patient health questionnaire (PHQ-9);    Healthcare setting;   

DOI  :  10.1186/s12888-022-03771-z

 received in 2021-07-25, accepted in 2022-01-27,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundDepression is a highly prevalent disease affecting more than 350 million people and has recently been associated with low-grade chronic inflammation. The role of diet in the development of a pro-inflammatory state was demonstrated in a recent study that found a high Empirical Dietary Inflammatory Index (EDII) score was associated with increased concentrations of circulating plasma inflammatory markers. It is becoming increasingly clear that diet and depression are linked, but the relationship itself has not been determined with absolute certainty. Pharmacologic and device assisted therapies are considered our most advanced treatments for major depressive disorder, though numerous studies suggest that they are not sufficient. Exploring the relationship of a pro-inflammatory diet and depressive symptoms is crucial for a holistic, evidenced-based approach to treating depression.MethodsOur study investigated this association using the EDII to evaluate the inflammatory potential of diet and Patient Health Questionnaire-9 (PHQ-9) to score depression among healthcare personnel. Results from 631 participants were collected for analysis using REDCap software.ResultsHigh PHQ-9 scores and high EDII scores were significantly correlated (F = 18.32, p < 0.0001) even when accounting for gender, psychiatric diagnosis, physical exercise, and spiritual exercise.ConclusionsOur findings suggest that anti-inflammatory diets can play a key role in the treatment of depression.

【 授权许可】

CC BY   
© The Author(s) 2022. corrected publication 2022