Analysis of gut microbiota diversity in Hashimoto’s thyroiditis patients

BMC Microbiology

Research

Fu Zhang¹  Juan Liao¹  Jilai Liu¹  Qing Lin¹  Boxi Lin¹  Xuejun Qin¹  Jing Cui¹ 

[1] Department of Clinical Laboratory, People’s Hospital Affiliated of Fujian University of Traditional Chinese Medicine, 350004, Fuzhou, China;

关键词: Hashimoto’s thyroiditis;    Gut microbiota;    16S rDNA;    High-throughput sequencing;    Biomarkers;   

DOI  :  10.1186/s12866-022-02739-z

 received in 2022-09-25, accepted in 2022-12-14,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundHashimoto’s thyroiditis (HT) is an autoimmune disease. Recent studies have found that the gut microbiota may play an important role in inducing HT, but there are no systematic studies on the changes in the gut microbiota during the development of HT.MethodsIn this study, 16S rDNA high-throughput sequencing technology in combination with the Kruskal–Wallis test, CCA/RDA analysis, Spearman correlation analysis, and other statistical methods were used to analyze the effects of age, gender, hormones, and other environmental factors on gut microbiota by comparing the differences in the microbiota at different stages of HT development.ResultsThe results showed that there were differences in the gut microbiota composition between healthy people (HCA) and in patients with HT. Lachnoclostridium, Bilophila, and Klebsiella were enriched in the HCA group, while Akkermansia, Lachnospiraceae, Bifidobacterium, Shuttleia, and Clostriworthdia were enriched in the HT group. Environmental factors analysis revealed that the Bifidobacterium and Klebsiella were two groups of bacteria that have undergone dramatic changes in HCA and HT, and mainly affected by gender. Romboutsia and Haemophilus regulated by the hormone of free triiodothyronine (FT3) may promote the development of HT, while Faecalibacterium and Lachnospiraceae regulated by free thyroxine (FT4) may protect the host.ConclusionsComprehensive studies have shown that gender is an important factor affecting gut microbial composition, but with the development of HT, hormones, age, and TSH begin to become dominant factors.

【 授权许可】

CC BY   
© The Author(s) 2022

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