Comparison of the cardiovascular system, clinical condition, and laboratory results in COVID-19 patients with and without vitamin D insufficiency

BMC Infectious Diseases

Research

Hossein Sheibani¹  Marzieh Rohani-Rasaf²  Erfan Kazemi³  Ali Mansoursamaei³ 

[1] Clinical Research Development Unit, Imam Hossein Hospital, Shahroud University of Medical Sciences, Imam Ave., 3616911151, Shahroud, Iran;Department of Epidemiology, School of Public Health, Shahroud University of Medical Sciences, Shahroud, Iran;Student Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran;

关键词: Vitamin D;    COVID-19;    Morbidity;    Mortality;    Cardiovascular;   

DOI  :  10.1186/s12879-022-07438-8

 received in 2021-11-05, accepted in 2022-05-03,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundSerum vitamin D levels may have a protective role against severe coronavirus disease 2019 (COVID-19). Studies have shown that deficiency in vitamin D may be a significant risk factor for poor outcomes. This study aims to compare the outcome and clinical condition of patients diagnosed with COVID-19 infection considering serum vitamin D levels.MethodsIn this cross-sectional study, 202 COVID-19 patients without known cardiovascular disease (reduced ejection fraction, uncontrolled arrhythmia, pericardial effusion, cardiac block, valvular disease, or hypertension) were included. Patients were divided into three groups of insufficient (< 30 ng/mL), normal (30 to 50 ng/mL), and high (> 50 ng/mL) serum vitamin D levels. Clinical outcome was defined as severe if invasive respiratory intervention and ICU admission was required.ResultsThe patients were divided into three groups based on their vitamin D level: 127 cases in the insufficient vitamin D group, 53 cases in the normal vitamin D group, and 22 cases in the high vitamin D group. The mean age of the population study was 56 years. Thirty-four patients had severe clinical outcomes. The distribution of this group was as follows: 21 patients in the insufficient vitamin D group (16.5%), eight patients in the normal vitamin D group (15.1%), and five patients in the high vitamin D group (22.7%); P = 0.74. No significant differences were found between the groups in terms of mortality rate (P = 0.46). Moreover, the mean of leukocytes (mean ± SD = 6873.5 ± 4236.2), ESR (mean ± SD = 38.42 ± 26.7), and CPK-MB (mean ± SD = 63 ± 140.7) were higher in the insufficient vitamin D group, but it was not statistically significant (P > 0.05).ConclusionThe finding of the present study showed that vitamin D could not make a significant difference in cardiovascular systems, laboratory results, and severity of the disease in COVID-19 patients.

【 授权许可】

CC BY   
© The Author(s) 2022. corrected publication 2022