Characteristics of hospitalized patients with COVID-19 during the first to fifth waves of infection: a report from the Japan COVID-19 Task Force

BMC Infectious Diseases

Research

Fukuki Saito¹  Naoki Hasegawa²  Ho Namkoong²  Yoshikazu Mutoh³  Yasushi Nakano⁴  Seishi Ogawa⁵  Norihiro Harada⁶  Yusuke Suzuki⁷  Tetsuya Ueda⁸  Takashi Ishiguro⁹  Koji Murakami^1,10  Ken Arimura^1,11  Yukinori Okada^1,12  Yuko Kitagawa^1,13  Takanori Kanai^1,14  Seiya Imoto^1,15  Koichi Fukunaga^1,16  Takanori Asakura^1,16  Atsuho Morita^1,16  Mayuko Watase^1,16  Makoto Ishii^1,16  Tatsuya Kusumoto^1,16  Hiromu Tanaka^1,16  Shiro Otake^1,16  Takahiro Fukushima^1,16  Shotaro Chubachi^1,16  Ho Lee^1,16  Kensuke Nakagawara^1,16  Hirofumi Kamata^1,16  Katsunori Masaki^1,16  Takashi Yoshiyama^1,17  Akinori Kimura^1,18  Soichiro Ueda^1,19  Satoru Miyano^2,20  Ryuji Koike^2,21 

[1] Department of Emergency and Critical Care Medicine, Kansai Medical University General Medical Center, Moriguchi, Japan;Department of Infectious Diseases, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-Ku, 160-8582, Tokyo, Japan;Department of Infectious Diseases, Tosei General Hospital, Seto, Japan;Department of Internal Medicine, Kawasaki Municipal Ida Hospital, Kawasaki, Japan;Department of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan;Department of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, Tokyo, Japan;Department of Respiratory Medicine, Kitasato University Kitasato Institute Hospital, Tokyo, Japan;Department of Respiratory Medicine, Osaka Saiseikai Nakatsu Hospital, Osaka, Japan;Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Kumagaya, Japan;Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan;Department of Respiratory Medicine, Tokyo Women’s Medical University, Tokyo, Japan;Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan;Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan;Department of Genome Informatics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan;Department of Surgery, Keio University School of Medicine, Tokyo, Japan;Division of Gastroenterology and Hepatology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan;Division of Health Medical Intelligence, Human Genome Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan;Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-Ku, 160-8582, Tokyo, Japan;Fukujuji Hospital, Kiyose, Japan;Institute of Research, Tokyo Medical and Dental University, Tokyo, Japan;JCHO (Japan Community Health Care Organization) Saitama Medical Center, Internal Medicine, Saitama, Japan;M&D Data Science Center, Tokyo Medical and Dental University, Tokyo, Japan;Medical Innovation Promotion Center, Tokyo Medical and Dental University, Tokyo, Japan;

关键词: COVID-19;    Wave of infection;    Respiratory infection;    Hospitalization;   

DOI  :  10.1186/s12879-022-07927-w

 received in 2022-07-28, accepted in 2022-12-06,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundWe aimed to elucidate differences in the characteristics of patients with coronavirus disease 2019 (COVID-19) requiring hospitalization in Japan, by COVID-19 waves, from conventional strains to the Delta variant.MethodsWe used secondary data from a database and performed a retrospective cohort study that included 3261 patients aged ≥ 18 years enrolled from 78 hospitals that participated in the Japan COVID-19 Task Force between February 2020 and September 2021.ResultsPatients hospitalized during the second (mean age, 53.2 years [standard deviation {SD}, ± 18.9]) and fifth (mean age, 50.7 years [SD ± 13.9]) COVID-19 waves had a lower mean age than those hospitalized during the other COVID-19 waves. Patients hospitalized during the first COVID-19 wave had a longer hospital stay (mean, 30.3 days [SD ± 21.5], p < 0.0001), and post-hospitalization complications, such as bacterial infections (21.3%, p < 0.0001), were also noticeable. In addition, there was an increase in the use of drugs such as remdesivir/baricitinib/tocilizumab/steroids during the latter COVID-19 waves. In the fifth COVID-19 wave, patients exhibited a greater number of presenting symptoms, and a higher percentage of patients required oxygen therapy at the time of admission. However, the percentage of patients requiring invasive mechanical ventilation was the highest in the first COVID-19 wave and the mortality rate was the highest in the third COVID-19 wave.ConclusionsWe identified differences in clinical characteristics of hospitalized patients with COVID-19 in each COVID-19 wave up to the fifth COVID-19 wave in Japan. The fifth COVID-19 wave was associated with greater disease severity on admission, the third COVID-19 wave had the highest mortality rate, and the first COVID-19 wave had the highest percentage of patients requiring mechanical ventilation.

【 授权许可】

CC BY   
© The Author(s) 2022

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