Role of IDO expression in patients with locally advanced rectal cancer treated with preoperative chemoradiotherapy

BMC Cancer

Research Article

Hideya Kashihara¹  Takuya Tokunaga¹  Toshiaki Yoshimoto¹  Shohei Okikawa¹  Chie Takasu¹  Kozo Yoshikawa¹  Toshihiro Nakao¹  Yuma Wada¹  Mitsuo Shimada¹  Masaaki Nishi¹  Shoko Yamashita¹ 

[1] Department of Surgery, University of Tokushima, 3-18-15 Kuramoto-cho, 770-8503, Tokushima, Japan;

关键词: PD-L1;    CRT;    Immune escape;    Neoadjuvant;   

DOI  :  10.1186/s12885-022-10357-1

 received in 2022-01-02, accepted in 2022-11-22,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundThe role of the immune system in locally advanced rectal cancer (LARC) following preoperative chemoradiotherapy (CRT) has been widely investigated in recent years. This study examined the prognostic significance of indoleamine-pyrrole 2,3-dioxygenase (IDO) expression in patients with LARC who received preoperative CRT.MethodsNinety patients with LARC who underwent preoperative CRT and curative resection were enrolled. IDO and programmed death-ligand 1 (PD-L1) expression was evaluated by immunohistochemistry.ResultsClinicopathological factors did not significantly differ between patients with positive or negative IDO expression, excluding the correlation of positive IDO expression with better tumor differentiation (p = 0.02). IDO expression was not associated with pathological response (p = 0.44), but it was associated with PD-L1 expression. The 5-year overall survival (OS) rate was significantly worse in the IDO-positive group than in the IDO-negative group (64.8% vs. 85.4%, p = 0.02). Univariate analysis identified IDO and PD-L1 expression (p = 0.02), surgical procedure (p = 0.01), final pathological stage (p = 0.003), lymph node metastasis (p < 0.001), and lymphatic invasion (p = 0.002) as significant prognostic factors for OS. Multivariate analysis revealed that IDO expression (HR: 7.10, p = 0.0006), surgical procedure (HR: 5.03, p = 0.01), lymph node metastasis (HR: 2.37, p = 0.04) and lymphatic invasion (HR: 4.97, p = 0.01) were independent prognostic indicators. Disease-free survival was not correlated with IDO or PD-L1 expression.ConclusionsIDO expression in patients with LARC who received preoperative CRT could be a potential prognostic indicator. IDO expression could be a useful marker for specifying individual treatment strategies in LARC.

【 授权许可】

CC BY   
© The Author(s) 2022

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