Predicting immunoglobulin resistance in Kawasaki disease: an assessment of neutrophil to lymphocyte platelet ratio

Italian Journal of Pediatrics

Research

Yuyao Lu¹  Bo Wang¹  Yunjia Tang¹  Xuan Li¹  Haitao Lv¹  Qiuqin Xu¹  Hui Chu¹  Yiming Qin²  Meihua Lu² 

[1] Department of Cardiology, Children’s Hospital of Soochow University, No. 92, Zhongnan Street, Suzhou, P.R. China;Department of Pediatrics, Changshu Hospital Affiliated to Nanjing University of Chinese Medicine, Changshu, No. 6, Huanghe Road, P.R. China;

关键词: Neutrophil to lymphocyte platelet ratio;    Intravenous immunoglobulin resistance;    Kawasaki disease;    Children;   

DOI  :  10.1186/s13052-022-01400-9

 received in 2022-10-20, accepted in 2022-12-20,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundKawasaki disease (KD) is an acute febrile illness of unknown etiology and predictors for intravenous immunoglobulin (IVIG) resistance have been widely explored in recent decades. Neutrophil to lymphocyte platelet ratio (NLPR) was reported to be associated with the outcomes in many diseases. However, its relationship with IVIG resistance has not be explored.MethodsThe medical data of patients diagnosed with KD in Children’s Hospital of Soochow University between January 2019 and December 2020 were retrospectively reviewed and analyzed. Patients were trisected into three groups based on NLPR. Logistics regression was used to analyze the association between NLPR and IVIG resistance. Restricted cubic spine was used to exhibit the relationship. Sensitivity analysis and subgroup analysis were also carried out.ResultsA total of 803 patients were included in the present study (61.8% males; median age: 24 months). IVIG resistance occurred in 74 (9.2%) patients. Multivariable-adjusted analyses revealed higher NLPR (odds ratio [95% confidence interval]: 1.12 [1.00-1.24]) was an independent predictor of IVIG resistance, which was strengthened by sensitivity analyses. The association of NLPR and IVIG resistance was not modified by age, sex, CALs, or days of IVIG initiation ≤ 4.ConclusionNLPR may be a valuable prognostic marker in KD patients with IVIG resistance.

【 授权许可】

CC BY   
© The Author(s) 2022

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