Protocol for a randomised controlled trial to investigate the effects of vitamin K2 on recovery from muscle-damaging resistance exercise in young and older adults—the TAKEOVER study

Trials

Study Protocol

Truls Raastad¹  Angus M. Hunter²  James Cobley³  Jennifer S. Lees⁴  Patrick B. Mark⁴  Carlos Celis-Morales⁴  Hannah Lithgow⁴  Terry J. Quinn⁴  Stuart R. Gray⁵  Frederick K. Ho⁶  Lynsey Johnston⁷ 

[1] Department of Physical Performance, Norwegian School of Sports Science, Oslo, Norway;Department of Sprots Science, Nottingham Trent University, Nottingham, UK;Division of Biomedical Sciences, University of Highlands and Islands, Inverness, UK;School of Cardiovascular and Metabolic Health, University of Glasgow, G12 8TA, Glasgow, UK;School of Cardiovascular and Metabolic Health, University of Glasgow, G12 8TA, Glasgow, UK;Department of Health Promotion and Rehabilitation, Lithuanian Sports University, Kaunas, Lithuania;School of Health and Wellbeing, University of Glasgow, Glasgow, UK;School of Life Sciences, University of Glasgow, Glasgow, UK;

关键词: Resistance exercise;    Muscle damage;    Recovery;    Inflammation;    Vitamin K;   

DOI  :  10.1186/s13063-022-06937-y

 received in 2021-10-26, accepted in 2022-11-16,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundRegular participation in resistance exercise is known to have broad-ranging health benefits and for this reason is prominent in the current physical activity guidelines. Recovery after such exercise is important for several populations across the age range and nutritional strategies to enhance recovery and modulate post-exercise physiological processes are widely studied, yet effective strategies remain elusive. Vitamin K2 supplementation has emerged as a potential candidate, and the aim of the current study, therefore, is to test the hypothesis that vitamin K2 supplementation can accelerate recovery, via modulation of the underlying physiological processes, following a bout of resistance exercise in young and older adults.MethodsThe current study is a two-arm randomised controlled trial which will be conducted in 80 (40 young (≤40 years) and 40 older (≥65 years)) adults to compare post-exercise recovery in those supplemented with vitamin K2 or placebo for a 12-week period. The primary outcome is muscle strength with secondary outcomes including pain-free range of motion, functional abilities, surface electromyography (sEMG) and markers of inflammation and oxidative stress.DiscussionEthical approval has been granted by the College of Medical Veterinary and Life Sciences Ethical Committee at the University of Glasgow (Project No 200190189) and recruitment is ongoing. Study findings will be disseminated through a presentation at scientific conferences and in scientific journals.Trial registrationClinicialTrials.gov NCT04676958. Prospectively registered on 21 December 2020.

【 授权许可】

CC BY   
© The Author(s) 2022

【 图 表 】

Fig. 1