Oral Juvenile Xanthogranuloma: a case report of gingival hyperplasia and osteolysis in male adult patient

BMC Oral Health

Case Report

Lin Feng¹  Long Chen²  Lingling E³ 

[1] Department of Oral and Maxillofacial Surgery, First Medical Center of Chinese PLA General Hospital, 100853, Beijing, China;Department of Stomatology, People’s Hospital of Mancheng District, 072150, Baoding, Hebei, China;Department of Oral and Maxillofacial Surgery, First Medical Center of Chinese PLA General Hospital, 100853, Beijing, China;Institute of Stomatology and Oral Maxilla Facial Key Laboratory, First Medical Center of Chinese PLA General Hospital, 100853, Beijing, China;

关键词: Juvenile Xanthogranuloma;    Non-Langerhans cell histiocytosis;    Case report;   

DOI  :  10.1186/s12903-022-02643-y

 received in 2022-07-23, accepted in 2022-11-30,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundJuvenile Xanthogranuloma (JXG) is a non-hereditary, self-limiting disease which is usually presented in infancy or early childhood and in males over females.Case presentationWe report a rare case of oral Juvenile Xanthogranuloma with recurrent progressive gingival hyperplasia and concomitant presentation of osteolysis in a 21-year-old adult male with no significant medical history. Patient presented with generalized gingival hyperplasia, osteolysis of the maxilla and mandible, and a round, firm, nodular mass with clear circumference on the left shoulder. Results of gingival tissue biopsy, karyotype, bone marrow biopsy and immunohistochemistry were suggestive of a diagnosis of Juvenile Xanthogranuloma with no association to hematologic malignancy. Unfortunately, patient declined treatment and elected to be transferred back to local hospital for future evaluation.ConclusionsJuvenile Xanthogranuloma in adults can have atypical manifestations including generalized gingival hyperplasia and osteolysis of the maxilla and mandible. It should be differentiated between Langerhans cell histiocytosis, Papillon–Lefevre Syndrome, and Pyogenic Granulomas. Despite uncommon incidence, it should be included in differential diagnoses in cases of similar clinical presentations.

【 授权许可】

CC BY   
© The Author(s) 2022

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