The correlation between triiodothyronine and the severity of liver fibrosis

BMC Endocrine Disorders

Research

Weiwei He¹  Xiaofang Zhang²  Mingzhu Lin²  Yinxiang Huang²  Yan Zhao²  Caoxin Huang²  Weijuan Su²  Shunhua Wang²  Peiying Huang²  Liying Wang²  Xiulin Shi³  Xuejun Li³ 

[1] School of Medicine, Xiamen University, Xiamen, China;Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, China;Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, Fujian, China;Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, China;Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, Fujian, China;Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, China;Fujian Provincial Key Laboratory of Translational Medicine for Diabetes, Xiamen, Fujian, China;Department of Endocrinology and Diabetes, The First Affiliated Hospital, Xiamen University, No.55 Zhenhai Road, 361003, Xaimen, China;

关键词: Non-alcoholic fatty liver disease;    Fibrosis;    Type 2 diabetes mellitus;    Free triiodothyronine;   

DOI  :  10.1186/s12902-022-01228-8

 received in 2022-07-25, accepted in 2022-11-23,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundThe severity of liver fibrosis is an important predictor of death in patients with non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM). However, there is still no definite conclusion on the relationship between triiodothyronine (T3) and the severity of liver fibrosis. Thus, the aim of this study was to analyze the correlation between T3 level and the severity of liver fibrosis.MethodsWe performed a cross-sectional study of 2072 T2DM patients with normal thyroid function from January 2017 to January 2020. NAFLD fibrosis score (NFS), Fibrosis index based on the 4 factors (FIB-4) and BARD score (BARD) were used to assess the severity of fibrosis in T2DM patients, and linear regression analyses were used to determine the factors independently associated with liver fibrosis. Further experiments were performed to assess the impact of low T3 on fibrosis progression in mice model and explore possible mechanisms.ResultsFree triiodothyronine (fT3) levels had significantly inverse correlations with NFS and FIB-4, and BARD in T2DM patients (P < 0.05). In multiple linear regression analyses, decreased fT3 level was an independent risk factor for the severity of liver fibrosis of T2DM patients (P < 0.01). Findings from in-vivo experiment using mice model proved that hypothyroidism mice had more severe of liver fibrosis than those mice with normal thyroid function. We also found that T3 could inhibit the profibrotic TREM2+CD9+ macrophage, which had been identified an important player in the progression of liver fibrosis.ConclusionThe findings from this study proved an inverse correlation between T3 level and the severity of liver fibrosis, and lower fT3 level within the normal range was an independent risk factor for severe liver fibrosis.

【 授权许可】

CC BY   
© The Author(s) 2022

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