Preliminary study on brain resting-state networks and cognitive impairments of patients with obstructive sleep apnea–hypopnea syndrome

BMC Neurology

Research Article

Yiding Ji¹  Yaqing He¹  Jiacheng Liu²  Junkang Shen³  Xiang Wang⁴  Qiaozhen Wu⁴ 

[1] Department of Radiology, Suzhou Ninth People’s Hospital, Suzhou, China;Department of Radiology, The Affiliated Zhongda Hospital of Southeast University Medical School, Nanjing, China;Department of Radiology, The Second Affiliated Hospital of Soochow University, Suzhou, China;Department of Respiratory, Suzhou Ninth People’s Hospital, Suzhou, China;

关键词: Obstructive sleep apnea;    Cognitive impairment;    Resting-state networks;    Independent component analysis;   

DOI  :  10.1186/s12883-022-02991-w

 received in 2022-07-07, accepted in 2022-11-25,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundTo investigate functional changes in brain resting-state networks (RSNs) in patients with obstructive sleep apnea–hypopnea syndrome (OSAHS) and their correlations with sleep breathing disorders and neurocognitive performance.MethodsIn this study, 18 OSAHS patients and 18 matched healthy controls underwent neurocognitive assessment and magnetic resonance imaging (MRI). Group-level independent component analysis (ICA) and statistical analyses were used to explore between-group differences in RSNs and the relationship between functional changes in RSNs, sleep breathing disorders and neurocognitive performance.ResultsThe OSAHS patients performed worse on neuropsychological tests than the healthy controls. Eight RSNs were identified, and between-group analyses showed that OSAHS patients displayed significantly decreased functional connectivity in the bilateral posterior cingulate gyri (PCC) within the default mode network (DMN), the right middle frontal gyrus (MFG) within the dorsal attention network (DAN), and the left superior temporal gyrus (STG) within the ventral attention network (VAN), and increased functional connectivity in the right superior frontal gyrus (SFG) within the salience network (SN). Further correlation analyses revealed that the average ICA z-scores in the bilateral PCC were correlated with sleep breathing disorders.ConclusionsOur findings demonstrate that the DMN, SN, DAN, and VAN are impaired during the resting state and are associated with decreased functionally distinct aspects of cognition in patients with OSAHS. Moreover, the intermittent hypoxia and sleep fragmentation caused by OSAHS are likely to be the main influencing factors.

【 授权许可】

CC BY   
© The Author(s) 2022

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