Sleep quality and influencing factors and correlation with T-lymphocyte subpopulation counts in patients with pulmonary tuberculosis: a cross-sectional study

BMC Infectious Diseases

Research

Wenqiu Chen¹  Jin Wang¹  Peize Zhang¹  Guofang Deng¹  Yi Lin¹  Hailin Zhang¹  Weiyu Wang¹  Jingfang Chen²  Youli Jiang³  Ao Li³ 

[1] Department of Pulmonary Medicine and Tuberculosis, The Third People’s Hospital of Shenzhen, Shenzhen, People’s Republic of China;Department of Pulmonary Medicine and Tuberculosis, The Third People’s Hospital of Shenzhen, Shenzhen, People’s Republic of China;Hengyang Medical School, School of Nursing, University of South China, Hengyang, People’s Republic of China;Hengyang Medical School, School of Nursing, University of South China, Hengyang, People’s Republic of China;

关键词: Pulmonary tuberculosis;    Sleep quality;    T-lymphocyte subpopulation count;    PSQI;    Influencing factors;   

DOI  :  10.1186/s12879-022-07946-7

 received in 2022-09-13, accepted in 2022-12-13,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundPatients diagnosed with pulmonary tuberculosis (TB) have poor sleep quality due to multiple factors. We aimed to assess the sleep status and related factors of TB patients in Shenzhen, China.MethodsA questionnaire survey was conducted on 461 TB patients hospitalized at Shenzhen Third People’s Hospital from March 2021 to January 2022, and sleep quality was assessed using the Pittsburgh sleep quality index (PSQI).ResultsA total of 459 valid questionnaires were collected, and 238 of the 459 TB patients had general or poor sleep quality (PSQI > 5). Patients’ gender, marriage, nutritional screening score, family atmosphere, fear of discrimination, fear of interactions, and the impact of the disease on their work life had significant effects on sleep quality (P < 0.05); PSQI scores of TB patients were negatively correlated with lymphocyte counts (r =  − 0.296, P < 0.01), T-lymphocyte counts (r =  − 0.293, P < 0.01), helper T lymphocyte counts (r =  − 0.283, P < 0.01), killer T lymphocyte counts (r =  − 0.182, P < 0.05), and were positively correlated with depression scores (r = 0.424, P < 0.01). Multivariable logistic regression analysis showed that male (OR = 1.64,95% CI 1.11–2.42, P < 0.05), unmarried (OR = 1.57, 95% CI 1.02–2.42, P < 0.05), NRS score grade 3(OR = 5.35, 95% CI 2.08–15.73, P < 0.01), general family atmosphere (OR = 2.23, 95% CI 1.07–4.93, P < 0.05), and the disease affecting work (OR = 1.66, 95% CI 1.11–2.50, P < 0.05) were factors influencing poor sleep quality.ConclusionMost TB patients had varying degrees of sleep disturbance, which may be affected by their gender, marriage, family atmosphere, nutritional status, the effect of the disease on work life, and, depression, as well as lower absolute T-lymphocyte subpopulation counts. Appropriate interventions should be implemented to improve their sleep quality, when treating or caring for such patients.

【 授权许可】

CC BY   
© The Author(s) 2022

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