Systematic analysis of relationships between plasma branched-chain amino acid concentrations and cardiometabolic parameters: an association and Mendelian randomization study

BMC Medicine

Research Article

Alexander Kurilshikov¹  Cisca Wijmenga¹  Alexandra Zhernakova¹  Jingyuan Fu²  Daoming Wang²  Lianmin Chen²  Marwah Doestzada²  Daria V. Zhernakova³  Inge C. L. van den Munckhof⁴  Niels P. Riksen⁴  Joost H. W. Rutten⁴  Leo A. B. Joosten⁴  Mihai G. Netea⁵  Vincent W. Bloks⁶  Martijn van Faassen⁶  Folkert Kuipers⁷ 

[1] Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands;Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands;Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands;Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands;Laboratory of Genomic Diversity, Center for Computer Technologies, ITMO University, St. Petersburg, Russia;Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands;Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands;Department for Genomics Immunoregulation, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany;Human Genomics Laboratory, Craiova University of Medicine and Pharmacy, Craiova, Romania;Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands;Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands;University of Groningen, University Medical Center Groningen, European Institute of Healthy Ageing (ERIBA), Groningen, the Netherlands;

关键词: Branched-chain amino acids;    Cardiometabolic diseases;    Population-based studies;    Mendelian randomization;   

DOI  :  10.1186/s12916-022-02688-4

 received in 2022-05-23, accepted in 2022-11-30,  发布年份 2022

来源: Springer

【 授权许可】

CC BY   
© The Author(s) 2022

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