The effect of a randomised controlled lifestyle intervention on weight loss and plasma proneurotensin

BMC Endocrine Disorders

卷:22

Research

Sara Lönn Larsson¹  Louise Bennet¹  Olle Melander²  Ayesha Fawad³  Joachim Struck⁴  Andreas Bergmann⁵ 

[1] Department of Clinical Sciences, Lund University, Malmö, Sweden;Clinical Trial Centre, Clinical Studies Sweden – Forum South, Skåne University Hospital in Lund, Jan Waldenströms gata 35, 205 02, Malmö, Sweden;

[2] Department of Clinical Sciences, Lund University, Malmö, Sweden;Lund University Diabetes Center, Lund University, Malmö, Sweden;Department of Internal Medicine, Skåne University Hospital, Malmö, Sweden;Metabolic Center, Region Skåne, Malmö, Sweden;

[3] Department of Clinical Sciences, Lund University, Malmö, Sweden;Metabolic Center, Region Skåne, Malmö, Sweden;

[4] Sphingotec GmbH, Hennigsdorf, Germany;

[5] Sphingotec GmbH, Hennigsdorf, Germany;Waltraut Bergmann Foundation, Hohen Neuendorf, Germany;

关键词: Proneurotensin;    Culturally adapted lifestyle intervention;    Weight loss;    Middle East;    Type 2 diabetes;    Migration;   

DOI  :  10.1186/s12902-022-01183-4

 received in 2022-01-30, accepted in 2022-10-19,  发布年份 2022

来源: Springer

【 摘 要 】

AimsProneurotensin (Pro-NT) is a strong predictor of cardiometabolic disease including type 2 diabetes and obesity, however, the effect of lifestyle change on Pro-NT has not been investigated in this context. Middle Eastern (ME) immigrants represent the largest and fastest growing minority population in Europe and are a high-risk population for obesity and type 2 diabetes. In this randomised controlled lifestyle intervention (RCT) addressing ME immigrants to Sweden where weight-loss was previously studied as the main outcome, as a secondary analysis we aimed to study change in Pro-NT during follow-up and if baseline Pro-NT predicted weight loss.MethodsImmigrants from the Middle East at high risk for type 2 diabetes were invited to participate in this RCT adapted lifestyle intervention of four months’ duration. The intervention group (N = 48) received a culturally adapted lifestyle intervention comprising seven group sessions and a cooking class addressing healthier diet and increased physical activity. The control group (N = 44) received treatment as usual with information to improve lifestyle habits on their own. Data assessed using mixed effects regression.OutcomesPrimary outcome; change in Pro-NT. Secondary outcome; change in BMI in relation to baseline plasma concentration of Pro-NT.ResultsDuring the four months follow up, weight was significantly reduced in the intervention (-2.5 kg) compared to the control group (0.8 kg) (β -0.12, 95% CI -0.24 to -0.01, P = 0.028). Pro-NT increased to a significantly greater extent in the intervention compared to the control group during follow up (28.2 vs. 3.5 pmol/L) (β 11.4; 4.8 to 18.02, P < 0.001). Change over time in BMI was associated with baseline Pro-NT (β 0.02; 0.01 to 0.04, P = 0.041).ConclusionIn consistence with data from surgical weight loss, this RCT paradoxically shows increased levels of Pro-NT during a multifactorial lifestyle intervention resulting in weight loss. Long term studies of Pro-NT following weight loss are needed.Trial registrationThis study is a secondary analysis of the RCT trial registered at www.clinicaltrials.gov. Registration number: NCT01420198. Date of registration 19/08/2011. The performance and results of this trial conform to the CONSORT 2010 guidelines.

【 授权许可】

CC BY   
© The Author(s) 2022

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