Global longitudinal strain assessment in contrast-enhanced echocardiography in breast cancer patients: a feasibility study

Cardiovascular Ultrasound

卷:21

Research

Mei Liu¹  Shichu Liang¹  Zhuoqin Tang¹  Zhiyue Liu¹  Yupei Qin¹  Xi Wang¹  Qian Li¹  He Huang¹  Ting Liang¹  Xiaorong Zhong² 

[1] Department of Cardiology, West China Hospital, Sichuan University, No.37 GuoXue Alley, 610041, Chengdu, China;

[2] Department of Head and Neck Oncology Cancer Center, West China Hospital, Sichuan University, 610041, Chengdu, China;Clinical Research Center for Breast, West China Hospital, Sichuan University, 610041, Chengdu, China;

关键词: Breast cancer;    Left ventricular global longitudinal strain;    Two-dimensional speckle-tracking echocardiography;    Contrast-enhanced echocardiography;    Autostrain;   

DOI  :  10.1186/s12947-023-00304-w

 received in 2022-12-04, accepted in 2023-04-02,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundLeft ventricular global longitudinal strain (GLS) obtained from two-dimensional speckle-tracking echocardiography (2D-STE) can reflect cancer therapy-related cardiac dysfunction in breast cancer (BC) patients, however, the accuracy and reproducibility of 2D-STE are restricted due to poor image quality.MethodsBetween January 2019 and October 2021, 160 consecutive BC patients aged ≥ 18 years were recruited. The 160 BC patients (mean age: 48.41 ± 9.93 years, 100% women) underwent both 2D-STE and Contrast-enhanced echocardiography (CEcho), 125 of whom were included in the measurement of GLS. The intraclass correlation coefficient (ICC) was used to determine the intra- and inter-observer reproducibility of 2D-STE and CEcho-STE. Correlation (r) was calculated using Pearson correlation. Statistical significance was set at P < 0.05.ResultsAmong 160 BC patients, more segments were recognized by CEcho-STE than by 2D-STE (2,771, 99.53% vs. 2,440, 84.72%). The left ventricular ejection fraction (LVEF) obtained by 2D was lower than CEcho (61.75 ± 6.59% vs. 64.14 ± 5.97%, P < 0.0001). The GLS obtained by 2D-STE was lower than CEcho-STE (-21.74 ± 2.77% vs. -26.79 ± 4.30%, P = 0.001). The ICC of the intraobserver and interobserver agreements in the CEcho-STE group was lower than that in the 2D-STE group. GLS measurements were in good agreement between the 2D-STE and CEcho-STE groups (r = 0.773).ConclusionsCEcho can overcome some imaging limitations and recognize more segments than 2D, which may provide an LVEF and GLS closer to the true value. Based on AutoStrain, CEcho-STE may serve as a complementary method for those with poor image quality.Graphical Abstract

【 授权许可】

CC BY   
© The Author(s) 2023

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