Neurobiological substrates of chronic low back pain (CLBP): a brain [99mTc]Tc-ECD SPECT study

European Journal of Hybrid Imaging

卷:6

Original Article

Oscar Della Pasqua¹  Vera Lúcia Lanchote²  Erica Negrini Lia³  Eduardo Barbosa Coelho⁴  Lauro Wichert-Ana⁵  Fabíola Dach⁶  Priscila Colavite Papassidero⁶  Leonardo Alexandre-Santos⁷  Lucas Emmanuel Lopes e Santos⁷  Ana Carolina Trevisan⁷  Jose Henrique Silvah⁷ 

[1] Clinical Pharmacology and Therapeutics, School of Life and Medical Sciences, University College London, London, UK;

[2] Department of Clinical Analysis, Food Science and Toxicology, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil;

[3] Department of Dentistry, School of Health Sciences, University of Brasilia (UnB), Brasilia, DF, Brazil;

[4] Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, SP, Brazil;

[5] Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, SP, Brazil;Nuclear Medicine and PET/CT Laboratory, Department of Medical Imaging, Hematology and Clinical Oncology, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, SP, Brazil;Seção de Medicina Nuclear, Hospital das Clínicas – FMRP – USP, 3900, Av. Bandeirantes, CEP: 14048-900, Ribeirão Preto, SP, Brasil;

[6] Department of Neurosciences and Behavioral Sciences, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, SP, Brazil;

[7] Nuclear Medicine and PET/CT Laboratory, Department of Medical Imaging, Hematology and Clinical Oncology, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, SP, Brazil;

关键词: Chronic low back pain;    Brain SPECT;    Neurobiological substrate;    Numeric rating scale;    Douleur Neuropathique 4 Questions;   

DOI  :  10.1186/s41824-022-00145-2

 received in 2022-05-30, accepted in 2022-07-18,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundRecent neuroimaging studies have demonstrated pathological mechanisms related to cerebral neuroplasticity in chronic low back pain (CLBP). Few studies have compared cerebral changes between patients with and without pain in the absence of an experimentally induced stimulus. We investigated the neurobiological substrates associated with chronic low back pain using [99mTc]Tc-ECD brain SPECT and correlated rCBF findings with the numeric rating scale (NRS) of pain and douleur neuropathique en 4 questions (DN4). Ten healthy control volunteers and fourteen patients with neuropathic CLBP due to lumbar disc herniation underwent cerebral SPECT scans. A quantitative comparison of rCBF findings between patients and controls was made using the Statistical Parametric Mapping (SPM), revealing clusters of voxels with a significant increase or decrease in rCBF. The intensity of CLBP was assessed by NRS and by DN4. RESULTS: The results demonstrated an rCBF increase in clusters A (occipital and posterior cingulate cortex) and B (right frontal) and a decrease in cluster C (superior parietal lobe and middle cingulate cortex). NRS scores were inversely and moderately correlated with the intensity of rCBF increase in cluster B, but not to rCBF changes in clusters A and C. DN4 scores did not correlate with rCBF changes in all three clusters. CONCLUSIONS: This study will be important for future therapeutic studies that aim to validate the association of rCBF findings with the pharmacokinetic and pharmacodynamic profiles of therapeutic challenges in pain.

【 授权许可】

CC BY   
© The Author(s) 2022

【 图 表 】

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