Different clinical features of children and adults in regional outbreak of Delta COVID-19

BMC Infectious Diseases

卷:22

Research

Qing-Qing Xing¹  Xuan Dong¹  Jin-Shui Pan²  Rongxian Qiu³  Mei-Zhu Hong⁴  Wei Chen⁴  Qin Li⁴  Hui Lin⁴ 

[1] Department of Hepatology, The First Affiliated Hospital of Fujian Medical University, No. 20, Chazhong Road, 350005, Fuzhou, Fujian, China;

[2] Department of Hepatology, The First Affiliated Hospital of Fujian Medical University, No. 20, Chazhong Road, 350005, Fuzhou, Fujian, China;Hepatology Research Institute, Fujian Medical University, No. 20, Chazhong Road, 350005, Fuzhou, Fujian, China;

[3] Department of Infectious Diseases, Affiliated Hospital of Putian College, Putian, Fujian, China;

[4] Department of Traditional Chinese Medicine, Mengchao Hepatobiliary Hospital of Fujian Medical University, No. 312, Xihong Road, 350025, Fuzhou, Fujian, China;

关键词: COVID-19;    Adult;    Child;    Clinical chemistry;    Symptom assessment;   

DOI  :  10.1186/s12879-022-07707-6

 received in 2022-03-11, accepted in 2022-08-22,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundThis study compared clinical features of the Delta variant of coronavirus disease 2019 (COVID-19) in children and adults.MethodsClinical data included 80 children and 132 adults with the Delta variant of COVID-19, hospitalized in the Affiliated Hospital of Putian College between September and October 2021. The data was analyzed retrospectively.ResultsThe proportion of mild patients in the children group (50%) was higher than that in the adults group (17.9%). Cough (25%, 20/80) and diarrhea (1.3%, 1/80) symptoms in children group were significantly less frequent. Compared with adults, there was no significant difference in the viral load of SARS-CoV-2 in samples collected by nasopharyngeal swabs. In children, lymphocyte count was higher [1.98 (0.25–4.25) vs 1.20 (0.29–4.27) ×109/L], whereas the interleukin-6 level was lower [5.87 (1.50–61.40) vs 15.15 (1.79–166.30) pg/mL] than that in adults group. Additionally, the incidence of liver injury in children group was lower than that in adults group. There was no significant difference in the incidence of proteinuria (22/75 vs 45/112) between the two groups, but the serum creatinine level in children was lower [42.0 (28.0–73.0) vs 57.0 (32.0–94.0) µmol/L].ConclusionCompared with adults, children with the Delta variant of COVID-19 have differences in symptoms, clinical classification, inflammatory indices, and liver/kidney function injury. Children’s illness is relatively mild. Clinicians should pay attention to their differences and use drugs accurately.

【 授权许可】

CC BY   
© The Author(s) 2022

【 图 表 】

Fig. 2