Health-related quality of life of men with primary osteoporosis and its changes after bisphosphonates treatment

BMC Musculoskeletal Disorders

卷:24

Research

Bing-na Zhou¹  Wei-bo Xia¹  Mei Li¹  Yan Jiang¹  Qian Zhang¹  Jing Hu¹  Di-chen Zhao¹  Xiao-yun Lin¹  Ou Wang¹  Xiao-ping Xing¹ 

[1] Department of Endocrinology, National Health Commission Key Laboratory of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shuaifuyuan No. 1, 100730, Beijing, Dongcheng District, China;

关键词: Osteoporosis;    Males;    HRQoL;    SF-36;    Bisphosphonates;   

DOI  :  10.1186/s12891-023-06397-8

 received in 2022-12-16, accepted in 2023-04-04,  发布年份 2023

来源: Springer

【 摘 要 】

IntroductionOsteoporosis leads to more serious consequences in men than in women, but less is known about its impacts on health-related quality of life (HRQoL) of men, and whether the anti-osteoporosis treatment can improve HRQoL of men with osteopenia/osteoprosis.MethodsWe enrolled men with primary osteoporosis and age-matched healthy controls. We collected medical history, serum levels of carboxyl-terminal type I collagen telopeptide, procollagen type I propeptides, and bone mineral density of patients. All patients and controls completed the short-form 36 (SF-36) questionnaires. Changes in HRQoL of osteopenia/osteoporosis men were prospectively evaluated after alendronate or zoledronic acid treatment.ResultsA total of 100 men with primary osteoporosis or osteopenia and 100 healthy men were included. The patients were divided into three subgroups: osteopenia (n = 35), osteoporosis (n = 39) and severe osteoporosis (n = 26). Men with osteoporosis or severe osteoporosis had impaired HRQoL in domains of physical health compared to healthy controls. HRQoL scores in physical health related domains of patients with severe osteoporosis were significantly lower compared to healthy controls, and were the poorest among the three subgroups of patients. Fragility fracture history was correlated with lower SF-36 scores about physical health. In 34 men with newly diagnosed osteoporosis receiving bisphosphonates treatment, HRQoL scores were significantly improved in domains of physical health after treatments.ConclusionsThe HRQoL is significantly impaired in men with osteoporosis, and the more severe the osteoporosis, the poorer the HRQoL. Fragility fracture is an important influencing factor of deteriorated HRQoL. Bisphosphonates treatment is beneficial to improve HRQoL of osteopenia/osteoporosis men.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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