Relationship between mean blood pressure during hospitalization and clinical outcome after acute ischemic stroke

BMC Neurology

卷:23

Research

Li Li¹  Qinghua Feng¹  Manyan Hu¹  Minghua Wu¹  Yunze Li¹  Yangjingyi Xia¹  Wenlei Li¹  Jiacheng Wu¹  Zhaoyao Chen¹  Tianrui Zhang¹  Yuan Zhu¹ 

[1] Department of Neurology, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, 155 Hanzhong Road, 210029, Nanjing, China;

关键词: Acute ischemic stroke;    Cerebral infarction;    Blood pressure;    Functional outcome;   

DOI  :  10.1186/s12883-023-03209-3

 received in 2023-01-01, accepted in 2023-04-14,  发布年份 2023

来源: Springer

【 摘 要 】

ObjectiveThe optimal blood pressure (BP) targets for acute ischemic stroke are unclear. We aimed to assess the relationship between Mean BP and clinical outcomes during hospitalization.Materials and methodsWe included 649 patients with Acute ischemic stroke (AIS) from December 2020 to July 2021. BP was measured daily, and mean blood pressure was calculated. Clinical events recorded within 90 days of randomization were: recurrent ischemic stroke, symptomatic intracranial hemorrhage, and death. The modified Rankin Scale (mRS) was used to measure primary outcomes 3 months after AIS. Logistic multiple regression analysis was performed by statistical software R.ResultThere is a nonlinear U-shaped relationship between SBP and poor outcomes. This means higher SBP and lower SBP will increase the incidence of poor outcomes. The optimal mean SBP during hospitalization was 135-150 mmHg, and patients with SBP < 135mmhg OR 2.4 [95% Cl, (1.16 ~ 4.97)], P = 0.018; and > 150mmhg OR 2.04 [95% Cl, 1.02 ~ 4.08], p = 0.045 had a higher probability of poor outcomes.ConclusionOur study shows that the optimal SBP of patients with AIS during hospitalization was 135-150 mmHg. The findings suggest that the relationship between mean SBP and 3-month functional outcome after AIS was U-shaped. Both higher SBP and lower SBP lead to poor prognosis in AIS patients.

【 授权许可】

CC BY   
© The Author(s) 2023

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