Clinical Outcome And Arginine Serum of Acute Ischemic Stroke Patients Supplemented by Snakehead Fish Extract

3rd International Conference on Tropical and Coastal Region Eco Development 2017

地球科学;生态环境科学

Pudjonarko, Dwi^1 ; Retnaningsih^1 ; Abidin, Zainal^1

Department of Neurology Faculty of Medicine Diponegoro University, Kariadi Central Hospital, Semarang, Indonesia^1

关键词: Acute ischemic stroke;    Anti-oxidant activities;    Fish extract;    Logistic regression analysis;    Logistic regressions;    National institute of healths;    NIHSS;    Random allocation;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/116/1/012028/pdf
DOI  :  10.1088/1755-1315/116/1/012028

学科分类：环境科学（综合）

来源: IOP

【 摘 要 】

Background: Levels of arginine associated with clinical outcome in acute ischemic stroke (AIS). Arginine is a protein needed to synthesis nitric oxide (NO), a potential vasodilator and antioxidant. Snakehead fish is a source of protein which has antioxidant activity. Snakehead fish contains mineral, vitamin, and amino acids. One of the amino acids that were found quite high in snakehead fish extract is arginine. The aim of this study was done to determine the effect of snakehead fish extracts (SFE) on serum arginin levels and clinical outcome of AIS patients. Methods: It was double-blind randomized pretest-posttest control group design, with. AIS patients were divided into two groups i.e. snakehead fish extracts (SFE) and control. SFE group were administered 15 grams SFE for 7 days . Arginine serum levels and clinical outcome (measured by National Institute of Health Stroke Scale = NIHSS) were measured before and after treatment, other related factors were also analyzed in Logistic regression. Results: A total of 42 subjects who were performed random allocation as SFE or control group. There was no differences in subject characteristics between the two groups. There was a differences Δ arginine serum levels between SFE and control (33.6±19.95 μmol/L; 0.3±2.51 μmol/L; p