Targeting the tumor stroma for cancer therapy

Molecular Cancer

卷:21

Review

Maosen Xu¹  Ruolan Xia¹  Xiawei Wei¹  Tao Zhang¹  Yuquan Wei¹ 

[1] Laboratory of Aging Research and Cancer Drug Target, State Key Laboratory of Biotherapy, West China Hospital, National Clinical Research Center for Geriatrics, Sichuan University, No. 17, Block 3, Southern Renmin Road, 610041, Chengdu, Sichuan, PR China;

关键词: Tumor stroma;    Extracellular matrix;    cancer-associated fibroblasts;    Mesenchymal stromal cells;    Pericytes;    cancer therapy;    Targeted therapy;    Clinical trial;   

DOI  :  10.1186/s12943-022-01670-1

 received in 2022-08-01, accepted in 2022-10-13,  发布年份 2022

来源: Springer

【 摘 要 】

Tumors are comprised of both cancer cells and surrounding stromal components. As an essential part of the tumor microenvironment, the tumor stroma is highly dynamic, heterogeneous and commonly tumor-type specific, and it mainly includes noncellular compositions such as the extracellular matrix and the unique cancer-associated vascular system as well as a wide variety of cellular components including activated cancer-associated fibroblasts, mesenchymal stromal cells, pericytes. All these elements operate with each other in a coordinated fashion and collectively promote cancer initiation, progression, metastasis and therapeutic resistance. Over the past few decades, numerous studies have been conducted to study the interaction and crosstalk between stromal components and neoplastic cells. Meanwhile, we have also witnessed an exponential increase in the investigation and recognition of the critical roles of tumor stroma in solid tumors. A series of clinical trials targeting the tumor stroma have been launched continually. In this review, we introduce and discuss current advances in the understanding of various stromal elements and their roles in cancers. We also elaborate on potential novel approaches for tumor-stroma-based therapeutic targeting, with the aim to promote the leap from bench to bedside.

【 授权许可】

CC BY   
© The Author(s) 2022

【 图 表 】

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