Synthesis and Antimicrobial Activity of Nitrogen-Containing Anthraquinone Derivatives

Iraqi Journal of Pharmaceutical Sciences

article

Vasyl Shupeniuk¹  Tatiana Taras¹  Oksana Sabadakh¹  Eugene Luchkevich¹  Mykola Matkivskyi¹ 

[1] Vasyl Stefanyk Precarpathian National University

关键词: antimicrobial activity;    nucleophilic substitution;    anthraquinone derivatives;    triazenes;    fungicidal activity;   

DOI  :  10.31351/vol31iss2pp193-201

学科分类：计算机网络和通讯

来源: College of Pharmacy University of Baghdad

【 摘 要 】

New substituted anthraquinones with amino derivations fragments were synthesized through the substitution of bromine atom by different amines using the Ullmann coupling reaction. Obtained compounds based on anthraquinone used for experimental antimicrobial studies. The structure of the synthesized compounds was confirmed by LC-MS and 1H, 13C NMR spectroscopy. Studies on planktonic microorganisms have shown that the first synthesized anthraquinone derivatives have an inhibitory effect against bacteria and fungi. The triazene 1-(3-(benzoic acid(triaz-1-en-1-ol(-4-(1H-imidazol-1-yl(-9,10-dioxo-9,10-dihydroanthracene -2-sulfonic acid, have wide spectrum of activity, growth retardation zones against gram-positive microorganisms in the range of 8.41-11.5 mm, gram-negative bacteria 5.87-8.18 mm, fungi of the genus Candida 5.81-7.48 mm. The high antimicrobial activity of this compound is probably due to the presence of benzoic acid in its molecule.

【 授权许可】

CC BY