Neoadjuvant radiotherapy in the approach of locally advanced breast cancer

ESMO Open

article

Cláudia Sousa¹  Mafalda Cruz¹  Ana Neto¹  Kayla Pereira¹  Marta Peixoto²  Joana Bastos³  Mónica Henriques¹  Domingos Roda¹  Rui Marques¹  Cristina Miranda¹  Gilberto Melo¹  Gabriela Sousa²  Paulo Figueiredo⁴  Paula Alves¹ 

[1] Radiotherapy, Instituto Português de Oncologia de Coimbra Francisco Gentil;Medical Oncology, Instituto Português de Oncologia de Coimbra Francisco Gentil;Regional Oncology Registry of the Centre, Instituto Português de Oncologia de Coimbra Francisco Gentil;Anatomical Pathology, Instituto Português de Oncologia de Coimbra Francisco Gentil

关键词: neoadjuvant therapy;    radiotherapy;    locally advanced;    breast cancer;    pathological response;   

DOI  :  10.1136/esmoopen-2019-000640

学科分类：社会科学、人文和艺术（综合）

来源: BMJ Publishing Group

【 摘 要 】

Background Approximately 4% of European patients are diagnosed with locally advanced breast cancer (LABC), a clinical condition commonly associated with poorer prognosis. Systemic therapy is the recommended initial treatment and when inoperability criteria prevails, radiotherapy (RT) should be used for tumour downstaging. This study intends to evaluate the impact of neoadjuvant radiotherapy (NART) in the treatment of inoperable LABC.Methods A retrospective study of female patients, submitted to the NART between January 2014 and December 2018 at our institution. The evaluation of pathological response (pR) was made based on Pinder criteria. Primary endpoint: pR. Secondary endpoints: overall survival (OS) and progression-free survival (PFS). OS and PFS were calculated using the Kaplan-Meier method. Differences between groups were compared using Student’s t-test, ANOVA (Analysis of variance) and χ2 test. The statistical analyses were performed using Stata (V.13).Results 90% is correlated with a better OS (p=0.004). Basal-like intrinsic subtype is correlated with worse OS and PFS (p<0.05). No relation was found between response and age, intrinsic subtype, treatment performed and clinical T stage.Conclusion 90% is correlated with a better OS. Prospective studies to explore predictive response biomarkers are necessary in order to improve patient selection and optimisation of the treatment.

【 授权许可】

CC BY|CC BY-NC-ND