SCAT8/miR-125b-5p axis triggers malignant progression of nasopharyngeal carcinoma through SCARB1

BMC Molecular and Cell Biology

article

Jiang, Chunmao¹  Feng, Dandan²  Zhang, Yu³  Yang, Kun⁴  Hu, Xiaotong¹  Xie, Qian¹ 

[1]Department of Health Management, Daping Hospital, Army Medical University

[2]Department of Otolaryngology Head and Neck Surgery, Daping Hospital, Army Medical University

[3]Department of Otolaryngology Head and Neck Surgery, the First Affiliated Hospital of Chongqing Medical University

[4]Department of Health Management Center, the Second Affiliated Hospital of Chongqing Medical University

关键词: Nasopharyngeal carcinoma;    ceRNA;    SCARB1;    Cell proliferation;    Cell migration;   

DOI  :  10.1186/s12860-023-00477-2

学科分类：内科医学

来源: Colegio Oficial de Psicologos

【 摘 要 】

Nasopharyngeal carcinoma is a tumor with high malignancy and poor prognosis, which severely affects the health of the patients. LncRNAs and microRNAs are crucial for the occurrence and development of nasopharyngeal carcinoma, which regulate the progression of nasopharyngeal carcinoma through the ceRNA network. SCARB1 plays an essential role in nasopharyngeal carcinoma. However, the mechanism underlying the regulation of SCARB1 in nasopharyngeal carcinoma through non-coding RNAs remains unclear. Our findings indicated that the SCAT8/miR-125b-5p axis promoted the malignant progression of nasopharyngeal carcinoma by driving the expression of SCARB1. Mechanistically, the expression of SCARB1 could be regulated by the lncRNA, SCAT8 and the microRNA, miR-125b-5p. Moreover, as a ceRNA of miR-125b-5p, SCAT8 can not only regulate the expression of SCARB1, but also regulate the malignant progression of nasopharyngeal carcinoma. Notably, our results reveal a novel ceRNA regulatory network in nasopharyngeal carcinoma, which could serve as a potential target for the diagnosis and treatment of nasopharyngeal carcinoma.

【 授权许可】

CC BY|CC0