Effect of siravedha in varicose vein – an exploratory data analysis and modelling

Annals of Ayurvedic Medicine

article

Jayasree R Kartha¹  Abhilash M²  Umesh P³  Ajitha K² 

[1] Department of Kriyasareera, PNNM Ayurveda Medical College and Hospital;Department of Kriyasareera, Government Ayurveda College;Department of Mathematics, College of Engineering

关键词: Ayurveda;    CEAP;    VCSS;    Quality of Life;    Hypoxia;    Systems biology;   

DOI  :  10.5455/AAM.50491

学科分类：医学（综合）

来源: Association of Ayurvedic Physicians of India

【 摘 要 】

Introduction: Siravedha (venesection) a type of bloodletting, is indicated for varicose vein in Ayurveda. Effects of siravedhamanifests at multiple levels from the blood hemodynamics to the Quality of Life of varicose vein patients. Present study wasplanned to understand the effect of siravedha in varicose vein in terms of all the available subjective and objective parameterswhich will give a better understanding on the effect of siravedha.ObjectiveTo develop a mathematical model for predicting the outcome of siravedha in varicose vein, using the data regarding clinicalstaging and blood profile.Materials and methodsA total of thirty subjects were recruited. Subjective and objective parameters were assessed at before and 15 days postsiravedha intervention. Subjective parameters were Clinical Etiologic Anatomic Pathophysiologic [CEAP] classification,Venous Clinical Severity Score [VCSS], Aberdeen Varicose Vein Questionnaire, scoring of raktadushti (vitiation of blood)symptoms and prakriti (body constitution) assessment whereas objective parameters include blood profile, Arterial BloodGas test etc.Results: Objective parameters in blood that showed a significant change after siravedha were RBC count in cubital vein,hematocrit in cubital and varicose vein, and also Red cell Distribution Width standard deviation (RDW – SD), MCV, basebuffer, partial pressure of oxygen, chloride ion and glucose level in varicose vein. Also there was significant improvement inthe subjective parameters - CEAP VCSS, AVVQ and raktadushti.Correlation between CEAP score and each parameter in cubital and varicose vein was done separately to find the highpositively and negatively correlated parameters and 11 parameters were identified. Parameters obtained are Neutrophil,Eosinophil, pH, SO2, HCO3, Chloride, RDW – SD, Mean Corpuscular Hemoglobin Concentration (MCHC), Glucose andLactate. Using physicochemical parameters as independent variables, CEAP the dependent variable, the CEAP was bestpredicted by linear regression model (R2 = 0.17) whereas VCSS by both linear (R2 = 0.21 ) and polynomial (R2 = 0.16) regressionmodels.Conclusions: Developing multi scale mathematical model provides more insight and clear understanding of effects of siravedhaon qualitative and quantitative parameters.

【 授权许可】

CC BY-NC-SA