Red cell distribution width is associated with cardiovascular risk in adults

Ciencia e Saude Coletiva

article

Carvalho, Natane Moreira de¹  Maluf, Chams Bicalho¹  Azevedo, Douglas Roberto Mesquita²  Reis, Rodrigo Citton Padilha dos³  Castilhos, Cristina Dickie de⁴  Barreto, Sandhi Maria²  Vidigal, Pedro Guatimosim¹ 

[1] Universidade Federal de Minas Gerais;UFMG;Universidade Federal do Rio Grande do Sul;UFRGS

关键词: Erythrocyte indices;    Cardiovascular diseases;    Risk;   

DOI  :  10.1590/1413-81232022277.15652021

学科分类：社会科学、人文和艺术（综合）

来源: Associacao Brasileira de Pos - Graduacao em Saude Coletiva

【 摘 要 】

Red cell distribution width (RDW) is a measure of erythrocyte size variability. Recent studies have shown that RDW is a predictive, and prognostic marker of mortality and cardiovascular (CVD) events in the general population and in CVD patients. This study aimed to investigate the association between RDW and CVD risk in a large sample of adults. A subsample of CVD free participants of the ELSA-Brasil cohort were included (n=4,481). In the cross-sectional approach, multiple regression analysis was used to investigate the association between RDW and the Framingham Risk Score (FRS). Linear mixed effect model evaluated whether baseline RDW predicted changes in CVD risk after about four-year follow up. Cross-sectional analysis showed that RDW was independently associated with FRS, participants in the fourth-quartile of RDW distribution had a 29% higher FRS than those in the first-quartile RDW (p<0.001). A longitudinal analysis revealed that RDW remained associated with increased FRS. In this large cohort of adult Brazilians, RDW was independently associated with increased CVD risk, as measured by the FRS, both at baseline and after four-year follow-up. However, RDW did not predict change in CVD risk in this short-term follow up.

【 授权许可】

CC BY