Revisão sistemática sobre os efeitos dos probióticos na depressão e ansiedade: terapêutica alternativa?

Ciencia e Saude Coletiva

article

Minayo, Miryam de Souza¹  Miranda, Iasmim²  Telhado, Raquel Senna² 

[1] Fundação Oswaldo Cruz;Laureate International Universities

关键词: Depression;    Anxiety;    Probiotics;    Microbiota;    Gut-brain axis;   

DOI  :  10.1590/1413-81232021269.21342020

学科分类：社会科学、人文和艺术（综合）

来源: Associacao Brasileira de Pos - Graduacao em Saude Coletiva

【 摘 要 】

This review aims to understand and analyse the effects of probiotics on depression, anxiety and psychological stress. These disorders are among the leading causes of disability worldwide. Conventional pharmacotherapies usually have a poor response or adverse side effects. In this context, recent studies have demonstrated a dense bi-directional communication named gut-brain axis. Evidences are demonstrating the relationship between disturbance in the enteric microbiome and psychiatric disorders, paving the way for the emergence of alternative therapies. A systematic search for randomized double/triple blind placebo-controlled clinical trials was performed in PubMed, Scopus and Lilacs. The studies selection followed the recommendations of the main items for report systematic reviews and meta-analyses (PRISMA). Nine articles met the criteria and were analysed for effects on depression, anxiety, psychological stress and biomarkers. Seven found positive results in at least one of the items. We concluded that the use of probiotics to alleviate depressive symptoms and anxiety is promising, mainly due to its potential anti-inflammatory effect, but additional and more rigorous double blind randomized clinical trials are necessary to endorse such conclusions.

【 授权许可】

CC BY