Intestinal microbiota, probiotics and mental health: from Metchnikoff to modern advances: Part II – contemporary contextual research

Gut Pathogens

Eva M Selhub²  Alan C Logan³  Alison C Bested¹ 

[1] Complex Chronic Diseases Program, BC Women's Hospital and Health Centre, B223A-4500 Oak Street, Vancouver, BC V6H 3N1, Canada;Harvard Medical School and Massachusetts General Hospital, 40 Crescent St., Suite 201, Waltham, MA 02453, USA;CAMNR, 775 Blithedale Avenue, Suite 364, Mill Valley, CA 94941, USA

关键词: Microbial ecosystems;    Intestinal permeability;    Diet;    Lipopolysaccharide endotoxin;    Microbial ecology;    Probiotics;    Anxiety;    Depression;    Autointoxication;    Intestinal microbiota;   

Others  :  821713
DOI  :  10.1186/1757-4749-5-3

 received in 2013-02-07, accepted in 2013-03-10,  发布年份 2013

【 摘 要 】

In recent years there has been a renewed interest concerning the ways in which the gastrointestinal tract – its functional integrity and microbial residents – might influence human mood (e.g. depression) and behavioral disorders. Once a hotbed of scientific interest in the early 20th century, this area lay dormant for decades, in part due to its association with the controversial term ‘autointoxication’. Here we review contemporary findings related to intestinal permeability, small intestinal bacterial overgrowth, lipopolysaccharide endotoxin (LPS) exposure, D-lactic acid, propionic acid, and discuss their relevance to microbiota and mental health. In addition, we include the context of modern dietary habits as they relate to depression, anxiety and their potential interaction with intestinal microbiota.

【 授权许可】

   
2013 Bested et al; licensee BioMed Central Ltd.

【 参考文献 】

• [1]Ferrao A, Kilman JE: Experimental toxic approach to mental illness. Psychiatr Q 1933, 7:115-153.
• [2]Logan AC, Venket Rao A, Irani D: Chronic fatigue syndrome: lactic acid bacteria may be of therapeutic value. Med Hypotheses 2003, 60:915-923.
• [3]Logan AC, Katzman M: Major depressive disorder: probiotics may be an adjuvant therapy. Med Hypotheses 2005, 64:533-538.
• [4]Reichenberg A, Yirmiya R, Schuld A, Kraus T, Haack M, Morag A, Pollmächer T: Cytokine-associated emotional and cognitive disturbances in humans. Arch Gen Psychiatry 2001, 58:445-452.
• [5]Naruszewicz M, Johansson ML, Zapolska-Downar D, Bukowska H: Effect of Lactobacillus plantarum 299v on cardiovascular disease risk factors in smokers. Am J Clin Nutr 2002, 76:1249-1255.
• [6]Lyte M, Varcoe JJ, Bailey MT: Anxiogenic effect of subclinical bacterial infection in mice in the absence of overt immune activation. Physiol Behav 1998, 65:63-68.
• [7]Benton D, Williams C, Brown A: Impact of consuming a milk drink containing a probiotic on mood and cognition. Eur J Clin Nutr 2007, 61:355-361.
• [8]Rao AV, Bested AC, Beaulne TM, Katzman MA, Iorio C, Berardi JM: A randomized, double-blind, placebo-controlled pilot study of a probiotic in emotional symptoms of chronic fatigue syndrome. Gut Pathog 2009, 1:6. BioMed Central Full Text
• [9]Messaoudi M, Lalonde R, Violle N, Javelot H, Desor D, Nejdi A: Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects. Br J Nutr 2011, 105:755-764.
• [10]Dinan TG, Quigley EM: Probiotics in the treatment of depression: science or science fiction? Aust N Z J Psychiatry 2011, 45:1023-1025.
• [11]Severance EG, Alaedini A, Yang S, Halling M, Gressitt KL, Stallings CR, Origoni AE, Vaughan C, Khushalani S, Leweke FM, Dickerson FB, Yolken RH: Gastrointestinal inflammation and associated immune activation in schizophrenia. Schizophr Res 2012, 138:48-53.
• [12]Critchfield JW, van Hemert S, Ash M, Mulder L, Ashwood P: The potential role of probiotics in the management of childhood autism spectrum disorders. Gastroenterol Res Pract 2011, 2011:161358.
• [13]Bijl RV, de Graaf R, Hiripi E, Kessler RC, Kohn R, Offord DR, Ustun TB, Vicente B, Vollebergh WA, Walters EE, Wittchen HU: The prevalence of treated and untreated mental disorders in five countries. Health Aff 2003, 22:122-133.
• [14]Dowlati Y, Herrmann N, Swardfager W, Liu H, Sham L, Reim EK, Lanctôt KL: A meta-analysis of cytokines in major depression. Biol Psychiatry 2010, 67:446-457.
• [15]Rawdin BS, Mellon SH, Dhabhar FS, Epel ES, Puterman E, Su Y, Burke HM, Reus VI, Rosser R, Hamilton SP, Nelson JC, Wolkowitz OM: Dysregulated relationship of inflammation and oxidative stress in major depression. Brain Behav Immun 2012.
• [16]Gibson SA, Korade Ž, Shelton RC: Oxidative stress and glutathione response in tissue cultures from persons with major depression. J Psychiatr Res 2012, 46:1326-1332.
• [17]Messay B, Lim A, Marsland AL: Current understanding of the bi-directional relationship of major depression with inflammation. Biol Mood Anxiety Disord 2012, 2:4. BioMed Central Full Text
• [18]Hannestad J, Gallezot JD, Schafbauer T, Lim K, Kloczynski T, Morris ED, Carson RE, Ding YS, Cosgrove KP: Endotoxin-induced systemic inflammation activates microglia: [11C]PBR28 positron emission tomography in nonhuman primates. NeuroImage 2012, 63:232-239.
• [19]Prager G, Hadamitzky M, Engler A, Doenlen R, Wirth T, Pacheco-López G, Krügel U, Schedlowski M, Engler H: Amygdaloid Signature of Peripheral Immune Activation by Bacterial Lipopolysaccharide or Staphylococcal Enterotoxin B. J Neuroimmune Pharmacol 2013, 8:42-50.
• [20]Grigoleit JS, Kullmann JS, Wolf OT, Hammes F, Wegner A, Jablonowski S, Engler H, Gizewski E, Oberbeck R, Schedlowski M: Dose-dependent effects of endotoxin on neurobehavioral functions in humans. PLoS One 2011, 6:e28330.
• [21]Kullmann JS, Grigoleit JS, Lichte P, Kobbe P, Rosenberger C, Banner C, Wolf OT, Engler H, Oberbeck R, Elsenbruch S, Bingel U, Forsting M, Gizewski ER, Schedlowski M: Neural response to emotional stimuli during experimental human endotoxemia. Hum Brain Mapp 2012.
• [22]Dellagioia N, Devine L, Pittman B, Hannestad J: Bupropion pre-treatment of endotoxin-induced depressive symptoms. Brain Behav Immun 2012.
• [23]Benson S, Kattoor J, Wegner A, Hammes F, Reidick D, Grigoleit JS, Engler H, Oberbeck R, Schedlowski M, Elsenbruch S: Acute experimental endotoxemia induces visceral hypersensitivity and altered pain evaluation in healthy humans. Pain 2012, 153:794-799.
• [24]Moreira AP, Texeira TF, Ferreira AB, Peluzio Mdo C, Alfenas RC: Influence of a high-fat diet on gut microbiota, intestinal permeability and metabolic endotoxaemia. Br J Nutr 2012, 108:801-809.
• [25]Sun L, Yu Z, Ye X, Zou S, Li H, Yu D, Wu H, Chen Y, Dore J, Clément K, Hu FB, Lin X: A marker of endotoxemia is associated with obesity and related metabolic disorders in apparently healthy Chinese. Diabetes Care 2010, 33:1925-1932.
• [26]Miller MA, McTernan PG, Harte AL, Silva NF, Strazzullo P, Alberti KG, Kumar S, Cappuccio FP: Ethnic and sex differences in circulating endotoxin levels: A novel marker of atherosclerotic and cardiovascular risk in a British multi-ethnic population. Atherosclerosis 2009, 203:494-502.
• [27]Pussinen PJ, Havulinna AS, Lehto M, Sundvall J, Salomaa V: Endotoxemia is associated with an increased risk of incident diabetes. Diabetes Care 2011, 34:392-397.
• [28]Vaishnava S, Hooper LV: Alkaline phosphatase: keeping the peace at the gut epithelial surface. Cell Host Microbe 2007, 2:365-367.
• [29]Kour K, Bani S: Chicoric acid regulates behavioral and biochemical alterations induced by chronic stress in experimental Swiss albino mice. Pharmacol Biochem Behav 2011, 99:342-348.
• [30]Engler H, Doenlen R, Engler A, Riether C, Prager G, Niemi MB, Pacheco-López G, Krügel U, Schedlowski M: Acute amygdaloid response to systemic inflammation. Brain Behav Immun 2011, 25:1384-1392.
• [31]Haba R, Shintani N, Onaka Y, Wang H, Takenaga R, Hayata A, Baba A, Hashimoto H: Lipopolysaccharide affects exploratory behaviors toward novel objects by impairing cognition and/or motivation in mice: Possible role of activation of the central amygdala. Behav Brain Res 2012, 228:423-431.
• [32]Miura H, Shirokawa T, Isobe K, Ozaki N: Shifting the balance of brain tryptophan metabolism elicited by isolation housing and systemic administration of lipopolysaccharide in mice. Stress 2009, 12:206-214.
• [33]Dobos N, de Vries EF, Kema IP, Patas K, Prins M, Nijholt IM, Dierckx RA, Korf J, den Boer JA, Luiten PG, Eisel UL: The role of indoleamine 2,3-dioxygenase in a mouse model of neuroinflammation-induced depression. Alzheimers Dis 2012, 28:905-915.
• [34]Salazar A, Gonzalez-Rivera BL, Redus L, Parrott JM, O'Connor JC: Indoleamine 2,3-dioxygenase mediates anhedonia and anxiety-like behaviors caused by peripheral lipopolysaccharide immune challenge. Horm Behav 2012, 62:202-209.
• [35]Kuc D, Zgrajka W, Parada-Turska J, Urbanik-Sypniewska T, Turski WA: Micromolar concentration of kynurenic acid in rat small intestine. Amino Acids 2008, 35:503-505.
• [36]Turski MP, Turska M, Zgrajka W, Kuc D, Turski WA: Presence of kynurenic acid in food and honeybee products. Amino Acids 2009, 36:75-80.
• [37]Lapin IP: Antagonism of kynurenic acid to anxiogens in mice. Life Sci 1998, 63:PL231-PL236.
• [38]Murray CL, Skelly DT, Cunningham C: Exacerbation of CNS inflammation and neurodegeneration by systemic LPS treatment is independent of circulating IL-1β and IL-6. J Neuroinflammation 2011, 8:50. BioMed Central Full Text
• [39]Cardoso FL, Kittel A, Veszelka S, Palmela I, Tóth A, Brites D, Deli MA, Brito MA: Exposure to lipopolysaccharide and/or unconjugated bilirubin impair the integrity and function of brain microvascular endothelial cells. PLoS One 2012, 7:e35919.
• [40]Erickson MA, Hansen K, Banks WA: Inflammation-induced dysfunction of the low-density lipoprotein receptor-related protein-1 at the blood–brain barrier: protection by the antioxidant N-acetylcysteine. Brain Behav Immun 2012, 26:1085-1094.
• [41]Gao Y, Huang C, Zhao K, Ma L, Qiu X, Zhang L, Xiu Y, Chen L, Lu W, Huang C, Tang Y, Xiao Q: Depression as a risk factor for dementia and mild cognitive impairment: a meta-analysis of longitudinal studies. Int J Geriatr Psychiatry 2012.
• [42]Ramirez SH, Haskó J, Skuba A, Fan S, Dykstra H, McCormick R, Reichenbach N, Krizbai I, Mahadevan A, Zhang M, Tuma R, Son YJ, Persidsky Y: Activation of cannabinoid receptor 2 attenuates leukocyte-endothelial cell interactions and blood–brain barrier dysfunction under inflammatory conditions. J Neurosci 2012, 32:4004-4016.
• [43]Donovan I, Grundy G: Endocannabinoid modulation of jejunal afferent responses to LPS. Neurogastroenterol Motil 2012, 24:956-e465.
• [44]Audet MC, Jacobson-Pick S, Wann BP, Anisman H: Social defeat promotes specific cytokine variations within the prefrontal cortex upon subsequent aggressive or endotoxin challenges. Brain Behav Immun 2011, 25:1197-1205.
• [45]Johnson AV, Goodall E: On the action of the blood serum from cases of acute mental disorder on B. coli communis. Br Med J 1904, 1:826-827.
• [46]Maes M, Kubera M, Leunis JC, Berk M, Geffard M, Bosmans E: In depression, bacterial translocation may drive inflammatory responses, oxidative and nitrosative stress (O&NS), and autoimmune responses directed against O&NS-damaged neoepitopes. Acta Psychiatr Scand 2012.
• [47]Maes M, Kubera M, Leunis JC, Berk M: Increased IgA and IgM responses against gut commensals in chronic depression: further evidence for increased bacterial translocation or leaky gut. J Affect Disord 2012, 141:55-62.
• [48]Maes M, Kubera M, Leunis JC: The gut-brain barrier in major depression: intestinal mucosal dysfunction with an increased translocation of LPS from gram negative enterobacteria (leaky gut) plays a role in the inflammatory pathophysiology of depression. Neuro Endocrinol Lett 2008, 29:117-124.
• [49]Leclercq S, Cani PD, Neyrinck AM, Stärkel P, Jamar F, Mikolajczak M, Delzenne NM, de Timary P: Role of intestinal permeability and inflammation in the biological and behavioral control of alcohol-dependent subjects. Brain Behav Immun 2012, 26:911-918.
• [50]Teixeira TF, Souza NC, Chiarello PG, Franceschini SC, Bressan J, Ferreira CL, Peluzio Mdo C: Intestinal permeability parameters in obese patients are correlated with metabolic syndrome risk factors. Clin Nutr 2012, 31:735-740.
• [51]Gummesson A, Carlsson LM, Storlien LH, Bäckhed F, Lundin P, Löfgren L, Stenlöf K, Lam YY, Fagerberg B, Carlsson B: Intestinal permeability is associated with visceral adiposity in healthy women. Obesity 2011, 19:2280-2282.
• [52]Goebel A, Buhner S, Schedel R, Lochs H, Sprotte G: Altered intestinal permeability in patients with primary fibromyalgia and in patients with complex regional pain syndrome. Rheumatology 2008, 47:1223-1227.
• [53]Maes M, Twisk FN, Kubera M, Ringel K, Leunis JC, Geffard M: Increased IgA responses to the LPS of commensal bacteria is associated with inflammation and activation of cell-mediated immunity in chronic fatigue syndrome. J Affect Disord 2012, 136:909-917.
• [54]de Magistris L, Familiari V, Pascotto A, Sapone A, Frolli A, Iardino P, Carteni M, De Rosa M, Francavilla R, Riegler G, Militerni R, Bravaccio C: Alterations of the intestinal barrier in patients with autism spectrum disorders and in their first-degree relatives. J Pediatr Gastroenterol Nutr 2010, 51:418-424.
• [55]Turck FB: The mechanism of intestinal atony in children – etiology and treatment. NY State J Med 1918, 18:1-6.
• [56]Alonso C, Guilarte M, Vicario M, Ramos L, Rezzi S, Martínez C, Lobo B, Martin FP, Pigrau M, González-Castro AM, Gallart M, Malagelada JR, Azpiroz F, Kochhar S, Santos J: Acute experimental stress evokes a differential gender-determined increase in human intestinal macromolecular permeability. Neurogastroenterol Motil 2012, 24:740-746. e348-9
• [57]van Wijck K, Lenaerts K, Grootjans J, Wijnands KA, Poeze M, van Loon LJ, Dejong CH, Buurman WA: Physiology and pathophysiology of splanchnic hypoperfusion and intestinal injury during exercise: strategies for evaluation and prevention. Am J Physiol Gastrointest Liver Physiol 2012, 303:G155-G168.
• [58]Ruuskanen A, Kaukinen K, Collin P, Huhtala H, Valve R, Mäki M, Luostarinen L: Positive serum antigliadin antibodies without celiac disease in the elderly population: does it matter? Scand J Gastroenterol 2010, 45:1197-1202.
• [59]Fitzgerald EF, Belanger EE, Gomez MI, Cayo M, McCaffrey RJ, Seegal RF, Jansing RL, Hwang SA, Hicks HE: Polychlorinated biphenyl exposure and neuropsychological status among older residents of upper Hudson River communities. Environ Health Perspect 2008, 116:209-215.
• [60]Choi YJ, Seelbach MJ, Pu H, Eum SY, Chen L, Zhang B, Hennig B, Toborek M: Polychlorinated biphenyls disrupt intestinal integrity via NADPH oxidase-induced alterations of tight junction protein expression. Environ Health Perspect 2010, 118:976-981.
• [61]Seelbach M, Chen L, Powell A, Choi YJ, Zhang B, Hennig B, Toborek M: Polychlorinated biphenyls disrupt blood–brain barrier integrity and promote brain metastasis formation. Environ Health Perspect 2010, 118:479-484.
• [62]Oishi K, Sato T, Yokoi W, Yoshida Y, Ito M, Sawada H: Effect of probiotics, Bifidobacterium breve and Lactobacillus casei, on bisphenol A exposure in rats. Biosci Biotechnol Biochem 2008, 72:1409-1415.
• [63]Fischbach R: Gastric acid production and iron metabolism in depressive states. Pharmakopsychiatr Neuropsychopharmakol 1973, 6:247-251.
• [64]Nakagawa T, Kawano T, Nagato H, Kimura M, Takayama T: A clinical and psychophysiological study of depression in internal medicine. Psychosomatics 1976, 17:173-179.
• [65]Lombardo L, Foti M, Ruggia O, Chiecchio A: Increased incidence of small intestinal bacterial overgrowth during proton pump inhibitor therapy. Clin Gastroenterol Hepatol 2010, 8:504-508.
• [66]Bures J, Cyrany J, Kohoutova D, Förstl M, Rejchrt S, Kvetina J: Small intestinal bacterial overgrowth syndrome. World J Gastroenterol 2010, 16:2978-2990.
• [67]Pyleris E, Giamarellos-Bourboulis EJ, Tzivras D, Koussoulas V, Barbatzas C, Pimentel M: The prevalence of overgrowth by aerobic bacteria in the small intestine by small bowel culture: relationship with irritable bowel syndrome. Dig Dis Sci 2012, 57:1321-1329.
• [68]Madrid AM, Poniachik J, Quera R, Defilippi C: Small intestinal clustered contractions and bacterial overgrowth: a frequent finding in obese patients. Dig Dis Sci 2011, 56:155-160.
• [69]Pimentel M, Wallace D, Hallegua D, Chow E, Kong Y, Park S, Lin HC: A link between irritable bowel syndrome and fibromyalgia may be related to findings on lactulose breath testing. Ann Rheum Dis 2004, 63:450-452.
• [70]Rana S, Bhansali A, Bhadada S, Sharma S, Kaur J, Singh K: Orocecal transit time and small intestinal bacterial overgrowth in type 2 diabetes patients from North India. Diabetes Technol Ther 2011, 13:1115-1120.
• [71]Addolorato G, Mirijello A, D'Angelo C, Leggio L, Ferrulli A, Abenavoli L: State and trait anxiety and depression in patients affected by gastrointestinal diseases: psychometric evaluation of 1641 patients referred to an internal medicine outpatient setting. Int J Clin Pract 2008, 62:1063-1069.
• [72]Kim KM, Kim BT, Lee DJ, Park SB, Joo NS, Kim YS, Kim KN: Erosive esophagitis may be related to small intestinal bacterial overgrowth. Scand J Gastroenterol 2012, 47:493-498.
• [73]Heading RC, Mönnikes H, Tholen A, Schmitt H: Prediction of response to PPI therapy and factors influencing treatment outcome in patients with GORD: a prospective pragmatic trial using pantoprazole. BMC Gastroenterol 2011, 11:52. BioMed Central Full Text
• [74]Pimentel M, Hallegua D, Chow EJ, Wallace D, Bonorris G, Lin HC: Eradication of small intestinal bacterial overgrowth decreases symptoms in chronic fatigue syndrome: a double blind, randomized study. Gastroenterology 2000, 118:A414.
• [75]Toskes PP: Bacterial overgrowth of the gastrointestinal tract. Adv Intern Med 1993, 38:387-407.
• [76]Lauritano EC, Valenza V, Sparano L, Scarpellini E, Gabrielli M, Cazzato A: Small intestinal bacterial overgrowth and intestinal permeability. Scand J Gastroenterol 2010, 45:1131-1132.
• [77]Wang SX, Wu WC: Effects of psychological stress on small intestinal motility and bacteria and mucosa in mice. World J Gastroenerol 2005, 11:2016-2021.
• [78]Morris TH, Sorensen SH, Turkington J, Batt RM: Diarrhoea and increased intestinal permeability in laboratory beagles associated with proximal small intestinal bacterial overgrowth. Lab Anim 1994, 28:313-319.
• [79]Barrett JS, Canale KE, Gearry RB, Irving PM, Gibson PR: Probiotic effects on intestinal fermentation patterns in patients with irritable bowel syndrome. World J Gastroenterol 2008, 14:5020-5024.
• [80]Ralph HJ, Volker DH, Chin J: Effects of omega-3 fatty acid deficiency on rat intestinal structure and microbiology. Asia Pac J Clin Nutr 2004, 13(Suppl):S79.
• [81]Fuller RA, Irvine KN, Devine-Wright P, Warren PH, Gaston KJ: Psychological benefits of greenspace increase with biodiversity. Biol Lett 2007, 3:390-394.
• [82]Luck GW, Davidson P, Boxall D, Smallbone L: Relations between urban bird and plant communities and human well-being and connection to nature. Conservation Biol 2011, 25:816-826.
• [83]Karlsson C, Ahrné S, Molin G, Berggren A, Palmquist I, Fredrikson GN, Jeppsson B: Probiotic therapy to men with incipient arteriosclerosis initiates increased bacterial diversity in colon: a randomized controlled trial. Atherosclerosis 2010, 208:228-233.
• [84]Hanski I, von Hertzen L, Fyhrquist N, Koskinen K, Torppa K, Laatikainen T, Karisola P, Auvinen P, Paulin L, Mäkelä MJ, Vartiainen E, Kosunen TU, Alenius H, Haahtela T: Environmental biodiversity, human microbiota, and allergy are interrelated. Proc Natl Acad Sci USA 2012, 109:8334-8339.
• [85]Vitali B, Minervini G, Rizzello CG, Spisni E, Maccaferri S, Brigidi P, Gobbetti M, Di Cagno R: Novel probiotic candidates for humans isolated from raw fruits and vegetables. Food Microbiol 2012, 31:116-125.
• [86]Benno Y, Suzuki K, Suzuki K, Narisawa K, Bruce WR, Mitsuoka T: Comparison of the fecal microflora in rural Japanese and urban Canadians. Microbiol Immunol 1986, 30:521-532.
• [87]Benno Y, Endo K, Mizutani T, Namba Y, Komori T, Mitsuoka T: Comparison of fecal microflora of elderly persons in rural and urban areas of Japan. Appl Environ Microbiol 1989, 55:1100-1105.
• [88]De Filippo C, Cavalieri D, Di Paola M, Ramazzotti M, Poullet JB, Massart S, Collini S, Pieraccini G, Lionetti P: Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proc Natl Acad Sci USA 2010, 107:14691-14696.
• [89]Yatsunenko T, Rey FE, Manary MJ, Trehan I, Dominguez-Bello MG, Contreras M, Magris M, Hidalgo G, Baldassano RN, Anokhin AP, Heath AC, Warner B, Reeder J, Kuczynski J, Caporaso JG, Lozupone CA, Lauber C, Clemente JC, Knights D, Knight R, Gordon JI: Human gut microbiome viewed across age and geography. Nature 2012, 486:222-227.
• [90]Moschen AR, Wieser V, Tilg H: Dietary factors: major regulators of the gut's microbiota. Gut Liver 2012, 6:411-416.
• [91]Knowles SR, Nelson EA, Palombo EA: Investigating the role of perceived stress on bacterial flora activity and salivary cortisol secretion: a possible mechanism underlying susceptibility to illness. Biol Psychol 2008, 77:132-137.
• [92]Lahtinen SJ, Tammela L, Korpela J, Parhiala R, Ahokoski H, Mykkänen H, Salminen SJ: Probiotics modulate the Bifidobacterium microbiota of elderly nursing home residents. AGE 2009, 31:59-66.
• [93]Ahmed M, Prasad J, Gill H, Stevenson L, Gopal P: Impact of consumption of different levels of Bifidobacterium lactis HN019 on the intestinal microflora of elderly human subjects. J Nutr Health Aging 2007, 11:26-31.
• [94]Qin J, Li Y, Cai Z, Li S, Zhu J, Zhang F, Liang S, Zhang W, Guan Y, Shen D, Peng Y, Zhang D, Jie Z, Wu W, Qin Y, Xue W, Li J, Han L, Lu D, Wu P, Dai Y, Sun X, Li Z, Tang A, Zhong S, Li X, Chen W, Xu R, Wang M, Feng Q, Gong M, Yu J, Zhang Y, Zhang M, Hansen T, Sanchez G, Raes J, Falony G, Okuda S, Almeida M, LeChatelier E, Renault P, Pons N, Batto JM, Zhang Z, Chen H, Yang R, Zheng W, Li S, Yang H, Wang J, Ehrlich SD, Nielsen R, Pedersen O, Kristiansen K, Wang J: A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature 2012, 490:55-60.
• [95]Carroll IM, Ringel-Kulka T, Siddle JP, Ringel Y: Alterations in composition and diversity of the intestinal microbiota in patients with diarrhea-predominant irritable bowel syndrome. Neurogastroenterol Motil 2012, 24:521-530. e248
• [96]Chassard C, Dapoigny M, Scott KP, Crouzet L, Del'homme C, Marquet P, Martin JC, Pickering G, Ardid D, Eschalier A, Dubray C, Flint HJ, Bernalier-Donadille A: Functional dysbiosis within the gut microbiota of patients with constipated-irritable bowel syndrome. Aliment Pharmacol Ther 2012, 35:828-838.
• [97]Ferrer M, Ruiz A, Lanza F, Haange SB, Oberbach A, Till H, Bargiela R, Campoy C, Segura MT, Richter M, von Bergen M, Seifert J, Suarez A: Microbiota from the distal guts of lean and obese adolescents exhibit partial functional redundancy besides clear differences in community structure. Environ Microbiol 2013, 15:211-226.
• [98]Sheedy JR, Wettenhall RE, Scanlon D, Gooley PR, Lewis DP, McGregor N, Stapleton DI, Butt HL, de Meirleir KL: Increased d-lactic Acid intestinal bacteria in patients with chronic fatigue syndrome. In Vivo 2009, 23:621-628.
• [99]Cani PD, Neyrinck AM, Fava F, Knauf C, Burcelin RG, Tuohy KM, Gibson GR, Delzenne NM: Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia. Diabetologia 2007, 50:2374-2383.
• [100]Pendyala S, Walker JM, Holt PR: A high-fat diet is associated with endotoxemia that originates from the gut. Gastroenterology 2012, 142:1100-1101. e2
• [101]Fava F, Gitau R, Griffin BA, Gibson GR, Tuohy KM, Lovegrove JA: The type and quantity of dietary fat and carbohydrate alter faecal microbiome and short-chain fatty acid excretion in a metabolic syndrome 'at-risk' population. Int J Obes 2013, 37:216-223.
• [102]Cani PD, Amar J, Iglesias MA, Poggi M, Knauf C, Bastelica D, Neyrinck AM, Fava F, Tuohy KM, Chabo C, Waget A, Delmée E, Cousin B, Sulpice T, Chamontin B, Ferrières J, Tanti JF, Gibson GR, Casteilla L, Delzenne NM, Alessi MC, Burcelin R: Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 2007, 56:1761-1772.
• [103]Davidson TL, Monnot A, Neal AU, Martin AA, Horton JJ, Zheng W: The effects of a high-energy diet on hippocampal-dependent discrimination performance and blood–brain barrier integrity differ for diet-induced obese and diet-resistant rats. Physiol Behav 2012, 107:26-33.
• [104]Freeman LR, Granholm AC: Vascular changes in rat hippocampus following a high saturated fat and cholesterol diet. J Cereb Blood Flow Metab 2012, 32:643-653.
• [105]Jacka FN, Mykletun A, Berk M, Bjelland I, Tell GS: The association between habitual diet quality and the common mental disorders in community-dwelling adults: the Hordaland Health study. Psychosom Med 2011, 73:483-490.
• [106]Jacka FN, Pasco JA, Mykletun A, Williams LJ, Hodge AM, O'Reilly SL, Nicholson GC, Kotowicz MA, Berk M: Association of Western and traditional diets with depression and anxiety in women. Am J Psychiatry 2010, 167:305-311.
• [107]Akbaraly TN, Brunner EJ, Ferrie JE, Marmot MG, Kivimaki M, Singh-Manoux A: Dietary pattern and depressive symptoms in middle age. Br J Psychiatry 2009, 195:408-413.
• [108]Sánchez-Villegas A, Delgado-Rodríguez M, Alonso A, Schlatter J, Lahortiga F, Serra Majem L, Martínez-González MA: Association of the Mediterranean dietary pattern with the incidence of depression: the Seguimiento Universidad de Navarra/University of Navarra follow-up (SUN) cohort. Arch Gen Psychiatry 2009, 66:1090-1098.
• [109]Sánchez-Villegas A, Toledo E, de Irala J, Ruiz-Canela M, Pla-Vidal J, Martínez-González MA: Fast-food and commercial baked goods consumption and the risk of depression. Public Health Nutr 2012, 15:424-432.
• [110]Crawford GB, Khedkar A, Flaws JA, Sorkin JD, Gallicchio L: Depressive symptoms and self-reported fast-food intake in midlife women. Prev Med 2011, 52:254-257.
• [111]Hirth JM, Rahman M, Berenson AB: The association of posttraumatic stress disorder with fast food and soda consumption and unhealthy weight loss behaviors among young women. J Womens Health 2011, 20:1141-1149.
• [112]Laugerette F, Furet JP, Debard C, Daira P, Loizon E, Géloën A, Soulage CO, Simonet C, Lefils-Lacourtablaise J, Bernoud-Hubac N, Bodennec J, Peretti N, Vidal H, Michalski MC: Oil composition of high-fat diet affects metabolic inflammation differently in connection with endotoxin receptors in mice. Am J Physiol Endocrinol Metab 2012, 302:E374-E386.
• [113]Willemsen LE, Koetsier MA, Balvers M, Beermann C, Stahl B, van Tol EA: Polyunsaturated fatty acids support epithelial barrier integrity and reduce IL-4 mediated permeability in vitro. Eur J Nutr 2008, 47:183-191.
• [114]Lam YY, Ha CW, Campbell CR, Mitchell AJ, Dinudom A, Oscarsson J, Cook DI, Hunt NH, Caterson ID, Holmes AJ, Storlien LH: Increased gut permeability and microbiota change associate with mesenteric fat inflammation and metabolic dysfunction in diet-induced obese mice. PLoS One 2012, 7:e34233.
• [115]Wall R, Marques TM, O'Sullivan O, Ross RP, Shanahan F, Quigley EM, Dinan TG, Kiely B, Fitzgerald GF, Cotter PD, Fouhy F, Stanton C: Contrasting effects of Bifidobacterium breve NCIMB 702258 and Bifidobacterium breve DPC 6330 on the composition of murine brain fatty acids and gut microbiota. Am J Clin Nutr 2012, 95:1278-1287.
• [116]Bergheim I, Weber S, Vos M, Krämer S, Volynets V, Kaserouni S, McClain CJ, Bischoff SC: Antibiotics protect against fructose-induced hepatic lipid accumulation in mice: role of endotoxin. Hepatol 2008, 48:983-992.
• [117]Duffey KJ, Popkin BM: High-fructose corn syrup: is this what's for dinner? Am J Clin Nutr 2008, 88:1722S-1732S.
• [118]Peet M: International variations in the outcome of schizophrenia and the prevalence of depression in relation to national dietary practices: an ecological analysis. Br J Psychiatry 2004, 184:404-408.
• [119]Westover AN, Marangell LB: A cross-national relationship between sugar consumption and major depression? Depress Anxiety 2002, 16:118-120.
• [120]Varea V, de Carpi JM, Puig C, Alda JA, Camacho E, Ormazabal A, Artuch R, Gómez L: Malabsorption of carbohydrates and depression in children and adolescents. J Pediatr Gastroenterol Nutr 2005, 40:561-565.
• [121]Ledochowski M, Widner B, Bair H, Probst T, Fuchs D: Fructose- and sorbitol-reduced diet improves mood and gastrointestinal disturbances in fructose malabsorbers. Scand J Gastroenterol 2000, 35:1048-1052.
• [122]Ledochowski M, Widner B, Murr C, Sperner-Unterweger B, Fuchs D: Fructose malabsorption is associated with decreased plasma tryptophan. Scand J Gastroenterol 2001, 36:367-371.
• [123]Wang HY, Qi LW, Wang CZ, Li P: Bioactivity enhancement of herbal supplements by intestinal microbiota focusing on ginsenosides. Am J Chin Med 2011, 39:1103-1115.
• [124]Del Rio D, Stalmach A, Calani L, Crozier A: Bioavailability of coffee chlorogenic acids and green tea flavan-3-ols. Nutrients 2010, 2:820-833.
• [125]Renouf M, Guy PA, Marmet C, Fraering AL, Longet K, Moulin J, Enslen M, Barron D, Dionisi F, Cavin C, Williamson G, Steiling H: Measurement of caffeic and ferulic acid equivalents in plasma after coffee consumption: small intestine and colon are key sites for coffee metabolism. Mol Nutr Food Res 2010, 54:760-766.
• [126]Stoupi S, Williamson G, Drynan JW, Barron D, Clifford MN: A comparison of the in vitro biotransformation of (−)-epicatechin and procyanidin B2 by human faecal microbiota. Mol Nutr Food Res 2010, 54:747-759.
• [127]Gross G, Jacobs DM, Peters S: In vitro bioconversion of polyphenols from black tea and red wine/grape juice by human intestinal microbiota displays strong inter-individual variability. J Agric Food Chem 2010, 58:10236-10246.
• [128]Devore EE, Kang JH, Breteler MM, Grodstein F: Dietary intakes of berries and flavonoids in relation to cognitive decline. Ann Neurol 2012, 72:135-143.
• [129]Nehlig A: The neuroprotective effects of cocoa flavanol and its influence on cognitive performance. Br J Clin Pharmacol 2013, 75:716-727.
• [130]Lucas M, Mirzaei F, Pan A, Okereke OI, Willett WC, O'Reilly ÉJ, Koenen K, Ascherio A: Coffee, caffeine, and risk of depression among women. Arch Intern Med 2011, 171:1571-1578.
• [131]Niu K, Hozawa A, Kuriyama S, Ebihara S, Guo H, Nakaya N, Ohmori-Matsuda K, Takahashi H, Masamune Y, Asada M, Sasaki S, Arai H, Awata S, Nagatomi R, Tsuji I: Green tea consumption is associated with depressive symptoms in the elderly. Am J Clin Nutr 2009, 90:1615-1622.
• [132]Ng TP, Chiam PC, Lee T, Chua HC, Lim L, Kua EH: Curry consumption and cognitive function in the elderly. Am J Epidemiol 2006, 164:898-906.
• [133]Jin JS, Touyama M, Hisada T, Benno Y: Effects of green tea consumption on human fecal microbiota with special reference to Bifidobacterium species. Microbiol Immunol 2012, 56:729-739.
• [134]Vendrame S, Guglielmetti S, Riso P, Arioli S, Klimis-Zacas D, Porrini M: Six-week consumption of a wild blueberry powder drink increases bifidobacteria in the human gut. Agric Food Chem 2011, 59:12815-12820.
• [135]Tzounis X, Rodriguez-Mateos A, Vulevic J, Gibson GR, Kwik-Uribe C, Spencer JP: Prebiotic evaluation of cocoa-derived flavanols in healthy humans by using a randomized, controlled, double-blind, crossover intervention study. Am J Clin Nutr 2011, 93:62-72.
• [136]Jaquet M, Rochat I, Moulin J, Cavin C, Bibiloni R: Impact of coffee consumption on the gut microbiota: a human volunteer study. Int J Food Microbiol 2009, 130:117-121.
• [137]Bereswill S, Muñoz M, Fischer A, Plickert R, Haag LM, Otto B, Kühl AA, Loddenkemper C, Göbel UB, Heimesaat MM: Anti-inflammatory effects of resveratrol, curcumin and simvastatin in acute small intestinal inflammation. PLoS One 2010, 5:e15099.
• [138]Kim DC, Ku SK, Lee W, Bae JS: Barrier protective activities of curcumin and its derivative. Inflamm Res 2012, 61:437-444.
• [139]Singal A, Tirkey N, Pilkhwal S, Chopra K: Green tea (Camellia sinensis) extract ameliorates endotoxin induced sickness behavior and liver damage in rat. Phytother Res 2006, 20:125-129.
• [140]Li J, Ye L, Wang X, Liu J, Wang Y, Zhou Y, Ho W: (−)-Epigallocatechin gallate inhibits endotoxin-induced expression of inflammatory cytokines in human cerebral microvascular endothelial cells. J Neuroinflammation 2012, 9:161. BioMed Central Full Text
• [141]Ghanim H, Sia CL, Upadhyay M, Korzeniewski K, Viswanathan P, Abuaysheh S, Mohanty P, Dandona P: Orange juice neutralizes the proinflammatory effect of a high-fat, high-carbohydrate meal and prevents endotoxin increase and Toll-like receptor expression. Am J Clin Nutr 2010, 91:940-949.
• [142]Lopresti AL, Hood SD, Drummond PD: Multiple antidepressant potential modes of action of curcumin: a review of its anti-inflammatory, monoaminergic, antioxidant, immune-modulating and neuroprotective effects. J Psychopharmacol 2012, 26:1512-1524.
• [143]Zhu WL, Shi HS, Wei YM, Wang SJ, Sun CY, Ding ZB, Lu L: Green tea polyphenols produce antidepressant-like effects in adult mice. Pharmacol Res 2012, 65:74-80.
• [144]Kumar B, Arora V, Kuhad A, Chopra K: Vaccinium myrtillus ameliorates unpredictable chronic mild stress induced depression: possible involvement of nitric oxide pathway. Phytother Res 2012, 26:488-497.
• [145]Mori-Okamoto J, Otawara-Hamamoto Y, Yamato H, Yoshimura H: Pomegranate extract improves a depressive state and bone properties in menopausal syndrome model ovariectomized mice. J Ethnopharmacol 2004, 92:93-101.
• [146]Yu Y, Wang R, Chen C, Du X, Ruan L, Sun J, Li J, Zhang L, O'Donnell JM, Pan J, Xu Y: Antidepressant-like effect of trans-resveratrol in chronic stress model: Behavioral and neurochemical evidences. Psychiatr Res 2013, 47:315-322.
• [147]Chepulis LM, Starkey NJ, Waas JR, Molan PC: The effects of long-term honey, sucrose or sugar-free diets on memory and anxiety in rats. Physiol Behav 2009, 97:359-368.
• [148]Kassim M, Achoui M, Mansor M, Yusoff KM: The inhibitory effects of Gelam honey and its extracts on nitric oxide and prostaglandin E(2) in inflammatory tissues. Fitoterapia 2010, 81:1196-1201.
• [149]Ezz El-Arab AM, Girgis SM, Hegazy EM, Abd El-Khalek AB: Effect of dietary honey on intestinal microflora and toxicity of mycotoxins in mice. BMC Complement Altern Med 2006, 6:6. BioMed Central Full Text
• [150]Li S, Zhao Y, Zhang L, Zhang X, Huang L, Li D, Niu C, Yang Z, Wang Q: Antioxidant activity of Lactobacillus plantarum strains isolated from traditional Chinese fermented foods. Food Chem 2012, 135:1914-1919.
• [151]Ahrne S, Hagslatt ML: Effect of lactobacilli on paracellular permeability in the gut. Nutrients 2011, 3:104-117.
• [152]Kim KM, Yu KW, Kang DH, Suh HJ: Anti-stress and anti-fatigue effect of fermented rice bran. Phytother Res 2002, 16:700-702.
• [153]Ducrotté P, Sawant P, Jayanthi V: Clinical trial: Lactobacillus plantarum 299v (DSM 9843) improves symptoms of irritable bowel syndrome. World J Gastroenterol 2012, 18:4012-4018.
• [154]Karlsson CL, Molin G, Fåk F, Johansson Hagslätt ML, Jakesevic M, Håkansson Å, Jeppsson B, Weström B, Ahrné S: Effects on weight gain and gut microbiota in rats given bacterial supplements and a high-energy-dense diet from fetal life through to 6 months of age. Br J Nutr 2011, 106:887-895.
• [155]Axling U, Olsson C, Xu J, Fernandez C, Larsson S, Ström K, Ahrné S, Holm C, Molin G, Berger K: Green tea powder and Lactobacillus plantarum affect gut microbiota, lipid metabolism and inflammation in high-fat fed C57BL/6J mice. Nutr Metab 2012, 9:105. BioMed Central Full Text
• [156]Chen H, Hayek S, Rivera Guzman J, Gillitt ND, Ibrahim SA, Jobin C, Sang S: The microbiota is essential for the generation of black tea theaflavins-derived metabolites. PLoS One 2012, 7:e51001.
• [157]Isik F, Tunali Akbay T, Yarat A, Genc Z, Pisiriciler R, Caliskan-Ak E, Cetinel S, Altıntas A, Sener G: Protective effects of black cumin (Nigella sativa) oil on TNBS-induced experimental colitis in rats. Dig Dis Sci 2011, 56:721-730.
• [158]Islam MT, Selim A, Sayed M, Khatun M, Siddiqui M, Alam M, Hossain M: Nigella sativa L. supplemented diet decreases egg cholesterol content and suppresses harmful intestinal bacteria in laying hens. J Anim Feed Sci 2011, 20:587-598.
• [159]Hosseini M, Zakeri S, Khoshdast S, Yousefian FT, Rastegar M, Vafaee F, Kahdouee S, Ghorbani F, Rakhshandeh H, Kazemi SA: The effects of Nigella sativa hydro-alcoholic extract and thymoquinone on lipopolysaccharide - induced depression like behavior in rats. J Pharm Bioallied Sci 2012, 4:219-225.
• [160]Zhang H, Wang J, Menghebilige M, Chen Y, Yun Y, Sun T, Li H, Guo M: Nutritive composition of Tarag, the traditional naturally-fermented goat milk in China. Ecol Food Nutr. 2009, 48:112-122.
• [161]Rahman MM, Kim WS, Ito T, Kumura H, Shimazaki K: Growth promotion and cell binding ability of bovine lactoferrin to Bifidobacterium longum. Anaerobe 2009, 15:133-137.
• [162]Drago-Serrano ME, de la Garza-Amaya M, Luna JS, Campos-Rodríguez R: Lactoferrin-lipopolysaccharide (LPS) binding as key to antibacterial and antiendotoxic effects. Int Immunopharmacol 2012, 12:1-9.
• [163]Maga EA, Desai PT, Weimer BC, Dao N, Kültz D, Murray JD: Consumption of lysozyme-rich milk can alter microbial fecal populations. Appl Environ Microbiol 2012, 78:6153-6160.
• [164]Marchbank T, Davison G, Oakes JR, Ghatei MA, Patterson M, Moyer MP, Playford RJ: The nutriceutical bovine colostrum truncates the increase in gut permeability caused by heavy exercise in athletes. Am J Physiol Gastrointest Liver Physiol 2011, 300:G477-G484.
• [165]Yary T, Aazami S, Soleimannejad K: Dietary intake of magnesium may modulate depression. Biol Trace Elem Res 2013, 151:324-329.
• [166]Pachikian BD, Neyrinck AM, Deldicque L, De Backer FC, Catry E, Dewulf EM, Sohet FM, Bindels LB, Everard A, Francaux M, Guiot Y, Cani PD, Delzenne NM: Changes in intestinal bifidobacteria levels are associated with the inflammatory response in magnesium-deficient mice. J Nutr 2010, 140:509-514.
• [167]Młyniec K, Davies CL, Budziszewska B, Opoka W, Reczyński W, Sowa-Kućma M, Doboszewska U, Pilc A, Nowak G: Time course of zinc deprivation-induced alterations of mice behavior in the forced swim test. Pharmacol Rep 2012, 64:567-575.
• [168]Zhong W, McClain CJ, Cave M, Kang YJ, Zhou Z: The role of zinc deficiency in alcohol-induced intestinal barrier dysfunction. Am J Physiol Gastrointest Liver Physiol 2010, 298:G625-G633.
• [169]Malo MS, Alam SN, Mostafa G, Zeller SJ, Johnson PV, Mohammad N, Chen KT, Moss AK, Ramasamy S, Faruqui A, Hodin S, Malo PS, Ebrahimi F, Biswas B, Narisawa S, Millán JL, Warren HS, Kaplan JB, Kitts CL, Hohmann EL, Hodin RA: Intestinal alkaline phosphatase preserves the normal homeostasis of gut microbiota. Gut 2010, 59:1476-1484.
• [170]Kawai Y, Ishii T, Morotomi M, Mutai M: Depression of activity of intestinal mucosal alkaline phosphatase with gastrointestinal microorganisms. Appl Environ Microbiol 1978, 36:381-383.
• [171]Zhao Y, Qin G, Sun Z, Che D, Bao N, Zhang X: Effects of soybean agglutinin on intestinal barrier permeability and tight junction protein expression in weaned piglets. Int J Mol Sci 2011, 12:8502-8512.
• [172]Ying C, Chunmin Y, Qingsen L, Mingzhou G, Yunsheng Y, Gaoping M, Ping W: Effects of simulated weightlessness on tight junction protein occludin and Zonula Occluden-1 expression levels in the intestinal mucosa of rats. Huazhong Univ Sci Technolog Med Sci 2011, 31:26-32.
• [173]Hanstock TL, Mallet PE, Clayton EH: Increased plasma d-lactic acid associated with impaired memory in rats. Physiol Behav 2010, 101:653-659.
• [174]Hanstock TL, Clayton EH, Li KM, Mallet PE: Anxiety and aggression associated with the fermentation of carbohydrates in the hindgut of rats. Physiol Behav 2004, 82:357-368.
• [175]Hanstock TL, Claytons EH, Mallet PE: Anxiety following increased hind-gut fermentation. Asia Pac J Clin Nutr 2003, 12(Suppl):S12.
• [176]Zhong SS, Song JX, Zhang ZS, Li SM, Wang L: The protective effects of bifidobacterial adhesin on ischemic reperfusion injury of intestine in rats. Zhonghua Nei Ke Za Zhi 2011, 50:863-867.
• [177]Tashiro Y, Kaneko W, Sun Y, Shibata K, Inokuma K, Zendo T, Sonomoto K: Continuous D-lactic acid production by a novel thermotolerant Lactobacillus delbrueckii subsp. lactis QU 41. Appl Microbiol Biotechnol 2011, 89:1741-1750.
• [178]Ben-Yahia L, Mayeur C, Rul F, Thomas M: Growth advantage of Streptococcus thermophilus over Lactobacillus bulgaricus in vitro and in the gastrointestinal tract of gnotobiotic rats. Benef Microbes 2012, 3:211-219.
• [179]Schepens MA, Rijnierse A, Schonewille AJ, Vink C, Brummer RJ, Willemsen LE, van der Meer R, Bovee-Oudenhoven IM: Dietary calcium decreases but short-chain fructo-oligosaccharides increase colonic permeability in rats. Br J Nutr 2010, 104:1780-1786.
• [180]Ewaschuk JB, Johnson IR, Madsen KL, Vasanthan T, Ball R, Field CJ: Barley-derived β-glucans increases gut permeability, ex vivo epithelial cell binding to E. coli, and naive T-cell proportions in weanling pigs. J Anim Sci 2012, 90:2652-2662.
• [181]Thomas RH, Meeking MM, Mepham JR, Tichenoff L, Possmayer F, Liu S, MacFabe DF: The enteric bacterial metabolite propionic acid alters brain and plasma phospholipid molecular species: further development of a rodent model of autism spectrum disorders. J Neuroinflammation 2012, 9:153. BioMed Central Full Text
• [182]Editors: Life without bacteria. JAMA 1912, 58:1603-1604.
• [183]Diaz Heijtz R, Wang S, Anuar F, Qian Y, Björkholm B, Samuelsson A, Hibberd ML, Forssberg H, Pettersson S: Normal gut microbiota modulates brain development and behavior. Proc Natl Acad Sci USA 2011, 108:3047-3052.
• [184]Neufeld KA, Kang N, Bienenstock J, Foster JA: Effects of intestinal microbiota on anxiety-like behavior. Commun Integr Biol 2011, 4:492-494.
• [185]Neufeld KM, Kang N, Bienenstock J, Foster JA: Reduced anxiety-like behavior and central neurochemical change in germ-free mice. Neurogastroenterol Motil 2011, 23:255-264.
• [186]Sudo N, Chida Y, Aiba Y, Sonoda J, Oyama N, Yu XN, Kubo C, Koga Y: Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice. J Physiol 2004, 558(Pt 1):263-275.
• [187]Gareau MG, Wine E, Rodrigues DM, Cho JH, Whary MT, Philpott DJ, Macqueen G, Sherman PM: Bacterial infection causes stress-induced memory dysfunction in mice. Gut 2011, 60:307-317.
• [188]Benson A, Pifer R, Behrendt CL, Hooper LV, Yarovinsky F: Gut commensal bacteria direct a protective immune response against Toxoplasma gondii. Cell Host Microbe 2009, 6:187-196.
• [189]Ennaceur A, Michalikova S, van Rensburg R, Chazot PL: Are benzodiazepines really anxiolytic? Evidence from a 3D maze spatial navigation task. Behav Brain Res 2008, 188:136-153.
• [190]Pedersen MG, Mortensen PB, Norgaard-Pedersen B, Postolache TT: Toxoplasma gondii infection and self-directed violence in mothers. Arch Gen Psychiatry 2012, 69:1123-1130.
• [191]Henriquez SA, Brett R, Alexander J, Pratt J, Roberts CW: Neuropsychiatric disease and Toxoplasma gondii infection. Neuroimmunomodulation 2009, 16:122-133.
• [192]De Martino B, Camerer CF, Adolphs R: Amygdala damage eliminates monetary loss aversion. Proc Natl Acad Sci USA 2010, 107:3788-3792.
• [193]Butler RK, Sharko AC, Oliver EM, Brito-Vargas P, Kaigler KF, Fadel JR, Wilson MA: Activation of phenotypically-distinct neuronal subpopulations of the rat amygdala following exposure to predator odor. Neuroscience 2011, 175:133-144.
• [194]Putman P, Antypa N, Crysovergi P, van der Does WA: Exogenous cortisol acutely influences motivated decision making in healthy young men. Psychopharmacology (Berl) 2010, 208:257-263.
• [195]Du Y, Yang M, Lee S, Behrendt CL, Hooper LV, Saghatelian A, Wan Y: Maternal western diet causes inflammatory milk and TLR2/4-dependent neonatal toxicity. Genes Dev 2012, 26:1306-1311.
• [196]Hooper LV, Wong MH, Thelin A, Hansson L, Falk PG, Gordon JI: Molecular analysis of commensal host-microbial relationships in the intestine. Science 2001, 291:881-884.
• [197]Desbonnet L, Garrett L, Clarke G, Bienenstock J, Dinan TG: The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat. J Psychiatr Res 2008, 43:164-174.
• [198]Ho JJ: Appropriate use of antibiotics in the NICU. East J Med 2010, 15:133-138.
• [199]Nosarti C, Reichenberg A, Murray RM, Cnattingius S, Lambe MP, Yin L, MacCabe J, Rifkin L, Hultman CM: Preterm birth and psychiatric disorders in young adult life. Arch Gen Psychiatry 2012, 69:E1-E8.
• [200]Khandaker GM, Zimbron J, Lewis G, Jones PB: Prenatal maternal infection, neurodevelopment and adult schizophrenia: a systematic review of population-based studies. Psychol Med 2013, 43:239-257.
• [201]Xu X, Hong X, Xie L, Li T, Yang Y, Zhang Q, Zhang G, Liu X: Gestational and lactational exposure to bisphenol-A affects anxiety- and depression-like behaviors in mice. Horm Behav 2012, 62:480-490.
• [202]Merrifield CA, Lewis MC, Claus SP, Pearce JT, Cloarec O, Duncker S, Heinzmann SS, Dumas ME, Kochhar S, Rezzi S, Mercenier A, Nicholson JK, Bailey M, Holmes E: Weaning diet induces sustained metabolic phenotype shift in the pig and influences host response to Bifidobacterium lactis NCC2818. Gut 2012.