Neuroimaging at 7 Tesla: a pictorial narrative review

Quantitative Imaging in Medicine and Surgery

article

Tomohisa Okada¹  Koji Fujimoto²  Yasutaka Fushimi³  Thai Akasaka¹  Dinh H. D. Thuy¹  Atsushi Shima¹  Nobukatsu Sawamoto⁴  Naoya Oishi⁵  Zhilin Zhang⁶  Takeshi Funaki⁷  Yuji Nakamoto³  Toshiya Murai⁶  Susumu Miyamoto⁷  Ryosuke Takahashi⁸  Tadashi Isa¹ 

[1] Human Brain Research Center, Graduate School of Medicine , Kyoto University;Department of Real World Data Research and Development, Graduate School of Medicine , Kyoto University;Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine , Kyoto University;Department of Human Health Sciences, Graduate School of Medicine , Kyoto University;Medial Innovation Center, Graduate School of Medicine , Kyoto University;Department of Psychiatry, Graduate School of Medicine , Kyoto University;Department of Neurosurgery, Graduate School of Medicine , Kyoto University;Department of Neurology, Graduate School of Medicine , Kyoto University

关键词: 7 Tesla (7T);    MP2RAGE;    susceptibility;    functional magnetic resonance imaging (fMRI);    magnetic resonance spectroscopy (MRS);   

DOI  :  10.21037/qims-21-969

学科分类：外科医学

来源: AME Publications

【 摘 要 】

Neuroimaging using the 7-Tesla (7T) human magnetic resonance (MR) system is rapidly gaining popularity after being approved for clinical use in the European Union and the USA. This trend is the same for functional MR imaging (MRI). The primary advantages of 7T over lower magnetic fields are its higher signal-to-noise and contrast-to-noise ratios, which provide high-resolution acquisitions and better contrast, making it easier to detect lesions and structural changes in brain disorders. Another advantage is the capability to measure a greater number of neurochemicals by virtue of the increased spectral resolution. Many structural and functional studies using 7T have been conducted to visualize details in the white matter and layers of the cortex and hippocampus, the subnucleus or regions of the putamen, the globus pallidus, thalamus and substantia nigra, and in small structures, such as the subthalamic nucleus, habenula, perforating arteries, and the perivascular space, that are difficult to observe at lower magnetic field strengths. The target disorders for 7T neuroimaging range from tumoral diseases to vascular, neurodegenerative, and psychiatric disorders, including Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, epilepsy, major depressive disorder, and schizophrenia. MR spectroscopy has also been used for research because of its increased chemical shift that separates overlapping peaks and resolves neurochemicals more effectively at 7T than a lower magnetic field. This paper presents a narrative review of these topics and an illustrative presentation of images obtained at 7T. We expect 7T neuroimaging to provide a new imaging biomarker of various brain disorders.

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