Quantitative parameters of diffusion tensor imaging in the evaluation of carpal tunnel syndrome

Quantitative Imaging in Medicine and Surgery

article

Ngoc Thanh Hoang¹  Duy Duan Nguyen²  Thi Hieu Dung Nguyen³  Trong Binh Le¹  Nghi Thanh Nhan Le⁴  Thanh Thao Nguyen¹  Nhu Quynh Vo¹ 

[1] Department of Radiology, University of Medicine and Pharmacy , Hue University;Department of Internal Medicine, University of Medicine and Pharmacy , Hue University;Department of Physiology, University of Medicine and Pharmacy , Hue University;Department of Surgery, University of Medicine and Pharmacy , Hue University

关键词: Carpal tunnel syndrome (CTS);    magnetic resonance imaging (MRI);    diffusion tensor imaging (DTI);    fraction anisotropy;    apparent diffusion coefficient (ADC);    Boston Carpal Tunnel Questionnaire;    nerve conduction study (NCS);   

DOI  :  10.21037/qims-21-910

学科分类：外科医学

来源: AME Publications

【 摘 要 】

Background: To explore the value of diffusion tensor imaging (DTI)-derived metrics in quantitative evaluation of carpal tunnel syndrome (CTS). Methods: This prospective cross-sectional study included 39 wrists from 24 symptomatic CTS patients, who underwent clinical, electrophysiological, and magnetic resonance imaging (MRI) evaluations. In addition, 10 wrists of 6 healthy participants were included as controls. Clinical and nerve conduction study (NCS) findings were evaluated and graded according to the Boston Carpal Tunnel Questionnaire (BCTQ) and the American Association of Neuromuscular and Electrodiagnostic Medicine (AANEM), respectively. We performed MRI using a 1.5 Tesla scanner. Mean diffusivity (MD), fractional anisotropy (FA), axial diffusivity (AD), and radial diffusivity (RD) of the median nerve at the distal radioulnar joint (DRUJ) (d), the inlet of the carpal tunnel (CT) at the pisiform level (i), the middle of the CT (m) and the outlet of the CT at the level of the hook of hamate (o), cross-sectional area at the inlet of the CT (iCSA), and the difference between MD and FA of the DRUJ and the outlet of CT (Delta MD and Delta FA) were measured. Results: The CTS patients had significantly lower FA [for example, oFA: mean difference 0.09, 95% confidence interval (CI): 0.05 to 0.12] and significantly higher MD than healthy participants (for example, iMD: mean difference 0.3, 95% CI: 0.03 to 0.57). There was a negative correlation between iCSA with iFA and between mFA and oFA (−0.5

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