Concussion Disrupts Normal Brain White Matter Microstructural Symmetry

Frontiers in Neurology

Jun Maruta¹  Eva M. Palacios²  Jacob M. Mallott²  Pratik Mukherjee³  Jamshid Ghajar⁵  Gary Sulioti⁷ 

[1] Brain Trauma Foundation, New York, NY, United States;Department Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States;Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, United States;Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, United States;Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, United States;Department of Rehabilitation and Human Performance, Icahn School of Medicine at Mount Sinai, New York, NY, United States;Duke University School of Medicine, Durham, NC, United States;

关键词: acute concussion;    bilateral homolog;    diffusion tensor imaging (DTI);    mild traumatic brain injury (mTBI);    magnetic resonance imaging (MRI);   

DOI  :  10.3389/fneur.2020.548220

来源: DOAJ

【 摘 要 】

Injuries and illnesses can alter the normal bilateral symmetry of the brain, and determining the extent of this disruption may be useful in characterizing the pathology. One way of quantifying brain symmetry is in terms of bilateral correlation of diffusion tensor metrics between homologous white matter tracts. With this approach, we hypothesized that the brains of patients with a concussion are more asymmetrical than those of healthy individuals without a history of a concussion. We scanned the brains of 35 normal individuals and 15 emergency department patients with a recent concussion. Fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were determined for regions of interest (ROI) defined by a standard white-matter atlas that included 21 bilateral ROIs. For each ROI pair, bilateral correlation coefficients were calculated and compared between the two subject groups. A symmetry index, defined as the ratio between the difference and the sum of bilateral measures, was also calculated for each ROI pair and compared between the groups. We found that in normal subjects, the extent of symmetry varied among regions and individuals, and at least subtle forms of structural lateralization were common across regions. In patients, higher asymmetry was found overall as well as in the corticospinal tract specifically. Results indicate that a concussion can manifest in brain asymmetry that deviates from a normal state. The clinical utility of characterizing post-concussion pathology as abnormal brain asymmetry merits further exploration.

【 授权许可】

Unknown